Affichage des articles dont le libellé est Assessment. Afficher tous les articles
Affichage des articles dont le libellé est Assessment. Afficher tous les articles

dimanche 24 novembre 2013

Chinese Medicine Theory – The Assessment of Depression Within the Framework of Chinese Medicine

Although any acupuncturist using this manual would be knowledgeable of the basic concepts of Chinese Medicine (CM), and would probably be familiar with the eight guiding criteria as a style of treatment, a complete section on the theoretical framework is included. This has been done for the sake of continuity as well as to introduce the nonacupuncture community to the Chinese Medicine conceptualization of depression. The aim is not only to provide a clinical tool for acupuncture practitioners but also to foster understanding and collaboration between acupuncturists, psychotherapists, physicians, and researchers.

Theoretical References

In the development of our treatment protocol for depression, we sought to integrate five areas or ‘filters’ (Seem 1985) which serve as the basis for assessment and treatment in acupuncture:

1. Yin/yang and eight guiding criteria

2. Viscera and bowels

Qi, blood and body fluidsChannels and network vesselsFive phases.

The pilot study outlined in a future post, as well the framework for this manual, are based primarily on the first three filters: (1) the eight guiding criteria, (2) viscera and bowels, and (3) qi, blood, and body fluids. These three filters are generally used together as a unit. Although the different theories that serve as the foundation for the five areas can be artificially compartmentalized, in reality they function together as a whole, and are all necessary to understand the etiology and progression of imbalances. The approach presented in this manual aims to integrate what we have found to be the most useful features of each ‘filter’ in the evaluation and treatment of depression, while emphasizing the use of the eight guiding criteria, viscera and bowels, and qi, blood and body fluids, as the foundation for treatment design. All five areas mentioned above are used in some way to explain the disease mechanisms that underlie depression, to understand the pattern differentiation characteristic of depressive episodes, and to outline the treatment principles and treatment strategies for point selection. We use the step-by-step methodology characteristic of eight principles pattern identification: (1) differentiate signs and symptoms using the four evaluations, (2) establish disease mechanisms, patterns, and pattern combinations, (3) outline treatment principles, and (4) design a treatment plan. We have, however, deviated from what is commonly known as traditional Chinese Medicine (TCM) in essentially three ways: first, we make extensive use of the five-phase theory in the initial interview to determine the specific nature of each person’s experience of depression; second, we encourage palpation of the abdominal area, and the channels for point selection; and third, we modify our point selection and total strategy over time, on the basis of channel interactions that are not emphasized in TCM. Such channel interactions are more broadly used by the Vietnamese and French acupuncture schools, some Japanese acupuncture styles, and the acupuncture style developed by Dr Mark Seem.

After having used this manual extensively, as both a clinical and a teaching tool, it became obvious that the treatment strategies that had been used consistently as part of our treatment protocol expanded the framework beyond the TCM model. The rationale for point selection, point combinations, and point location, although based on TCM (‘TCM is a style of Chinese Medicine that emerged predominantly from the People’s Republic of China in the twentieth century, and which is presented as the standard model of Chinese Medicine in mainland China today. For an interesting discussion of TCM, its history, development, and clinical standards, see Fruehauf (1999).) pattern differentiation, was heavily influenced by training under Mark Seem. Seem’s approach developed through the influence of the French energetic school of acupuncture, and the work of Dr Van Ghi. For this reason, the section that describes the channels and network vessels deviates from standard TCM theory to include a broader consideration of the complexity of the channel system, which has very little importance in TCM as a style of treatment today. Although purists in any of these traditions may argue against combining different styles of treatment, in reality the contemporary practice of acupuncture has emerged as a ‘weaving of lineages within the diverse traditions that make up Oriental medicine’ (Hougham 2000). In line with this view, the authors hope to make a small contribution towards the development of a foundation for a multidimensional energetic approach to the assessment and treatment of depression — one that allows the practitioner to stratify treatment options based on an integrated use of the five filters. It needs to be emphasized, however, that any system that may emerge from this endeavor — to be authentic and internally coherent — must develop on a solid foundation: one that is based on a clearly articulated theoretical framework and a consistent treatment methodology.

The authors recognize the validity and significance of diverse schools of thought in the treatment of depression with acupuncture. We selected the eight guiding criteria as the primary framework for our study because in our view: (1) the eight criteria offer a methodological approach that can be more easily replicated in control studies, (2) most of the existing research literature for acupuncture in the treatment of depression uses the eight guiding criteria directly or indirectly, (3) the reference literature available in English is based on these criteria, and (4) the eight guiding criteria as a style of treatment offers more consistent treatment protocols. It is of great interest to the authors to be able to compare — in the future — different styles of treatment and their clinical outcomes, but this was not an aim of our pilot study, nor of this category.

In order to establish a parallel between Western-defined major depression and acupuncture patterns of disharmony, we looked at depression as a complex interplay of disease mechanisms that develop from three main factors: (1) the patient’s predisposing tendency towards vacuity or repletion of either yin or yang, (2) the liver’s inability to maintain the free and smooth flow of qi, and (3) a disturbance in the heart’s function of housing the spirit (shen).

In this way, the question we pose within the context of Chinese Medicine is not only whether someone is depressed, but how this person is experiencing depression, and what precipitating factors — physical, psychological, and social — have contributed to his or her present condition. Chinese Medicine offers, then, a framework for understanding distinct symptom pictures and for developing a treatment approach based on the nature of each individual’s particular symptom pattern. Thus acupuncture treatments focus on the entire symptom picture, which includes physiological as well as psychiatric symptoms.

Chinese philosophy is based on the premise that all life occurs within a unified system, that all phenomena are manifestations of a unifying principle of energy or life force, and that all manifestations of life are connected and mutually dependent upon one another. Life unfolds as a process of differentiation that expresses the interaction between two complementary forces, yin and yang, which represent the totality of the dynamic equilibrium. This unified system is understood as a process of fluctuations and permanent change, as the cyclic nature of continuous movement. Everything can be characterized as either yin or yang, relative aspects of an alternating cycle along a single continuum (Beinfield & Korngold 1991). The creative principle that symbolizes life in all its forms and which activates every process that characterizes living entities is known as qi (pronounced `chee’) or `vital energy’, and is central to Chinese medical theory.

Human beings are considered a microcosm that reflects the universe that surrounds them — a dynamic series of energetic fluctuations constitutes the body as a living system (Seem 1987). Each of us is an ecosystem living within a larger ecosystem. The balance of forces within us determines our health and disease (Beinfield & Korngold 1991).

Acupuncture looks for disharmonies of qi and, strictly speaking, depression does not exist as a disease category in Chinese Medicine. When an acupuncturist using the eight-principles framework is asked to evaluate a ‘depressed’ person, he or she weaves all relevant information into a pattern of disharmony, a description of the dynamics that portray a situation of an imbalance. Symptoms are part of this imbalance which can be seen in other aspects of the patient’s life and behavior (Kaptchuck 1983). Because the patient is always considered as a body—mind continuum, somatic and psychological symptoms are equally important.

By focusing on the detection of qi imbalances, rather than on the diagnosis and treatment of disease, Chinese Medicine explains relation-ships between physiological and psychological events that are considered separate phenomena in the Western medical model. Chinese Medicine offers a physiology that postulates a clear connection between somatic events and psychological concepts of mind and emotion, helping to close the gap between soma and psyche (Seem 1987). As with any other diagnostic system, the theoretical framework provided by Chinese Medicine can be used to understand the appearance of symptoms that characterize depression, to account for the heterogeneity of symptom presentation in depression, and to devise individually-tailored treatments for particular constellations of depressive symptoms.

Chinese Medicine defines health as the balance between yin and yang, which depends on the capacity of an organism to adapt to change and maintain equilibrium. Sickness is the result of vacuity or repletion of either yin or yang. Vacuity is defined as: weakness of the forces (right qi) that maintain the health of the body and fight disease, an insufficiency of vital substances (yin, blood, body fluids, essence; i.e. yin humor), or the diminished capacity of physiological processes. Repletion is defined as: an accumulation of physiological products (phlegm, dampness, blood, and qi) that are harmful to the body and may obstruct functioning, or as the relative excess of either endogenous or exogenous pathogens (in Chinese Medicine endogenous or exogenous pathogens are known as ‘evil qi’ (xie). They include the six qi (wind, cold, fire, summerheat, dampness, and dryness) in their capacity to cause disease; the ‘warm evils’ (warm heat school), and various types of toxins. Additional pathogens are wind, cold, fire, dampness and dryness arising within the body, and static blood and phlegm produced by the body (Wiseman & Feng 1998).) that may threaten the health of the organism. Vacuity and repletion are both imbalances between yin and yang.

The homeostasis of an organism — the balance between yin and yang — is sustained by the proper circulation of qi along energetic pathways or meridians, commonly known as the channels and network vessels. The channels form a network that connects the surface of the body with the internal organs (viscera and bowels), serving as a two-way communication system, which both conveys messages to the surface about internal malfunctioning and alerts the internal functions about surface phenomena that might be threatening to move deeper into the system (Seem 1987). The channels and network vessels are the surface manifestations of the viscera and bowels, and act as an irrigation system that regulates the supply of qi and prevents accumulations. The internal organs in Chinese Medicine are defined by their functions and interrelations, rather than by their somatic structures or specific anatomic locations. They work as spheres of influence, and represent a complete set of functions that reflect energetic relationships among physiological and psychological events. In order not to confuse them with the biomedical entities of the same name, we refer to them as viscera (yin) and bowels (yang); they are also sometimes referred to as organic—energetic functional units, organ functions (Seem 1987), organ networks (Beinfield & Korngold 1991), or energetic orbs (Porkert 1983). There are five viscera and six bowels. The viscera and bowels and the channels both work in pairs, with one yin and one yang function interconnected:3 lung—large intestine, stomach—spleen, heart—small intestine, kidney—bladder, pericardium—triple heater, liver—gall bladder, yin and yang respectively.

The Chinese characters for yin and yang denote the sunny and shady sides of a mountain respectively. These two complementary and opposing principles are used to describe phenomena that have a similar quality and relationship, including the different functions and parts of the body. Yin and yang are rooted in each other: they are interdependent, relative to one another, divisible but inseparable. Yin and Yang counterbalance and complement each other and transform into each other.

The pericardium is considered as an extension of the functions of the heart and it is said to act as a buffer that protects the heart from external influences; it is not considered a separate viscera. In the context of the channels and network vessels, the pericardium is a channel in its own right and is considered the yin pair of the triple heater channel. Therefore, there are five (yin) viscera and six (yang) bowels; but there are six yin and six yang channels or meridians.

The potential for differentiation into yin and yang (earlier heaven), upon which life depends, is received from our parents at conception and stored in the kidney. The kidney has a very special relationship with the other viscera and bowels because it holds the foundation for their own yin and yang (Kaptchuk 1983). Each of the other viscera and bowels is considered to have a yin (storing, nour-ishing, cooling) component and a yang (activating, protective, warming) component, which are said to stem from the yin and yang roots of the kidney, respectively (Seem 1987). According to Kaptchuck (1983), yin is what sustains and conserves the organism and grants us the qualities of rest, tranquility, and quiescence; yin condenses and concentrates inwardly the energy of life. Yin moistens, softens, stabilizes, and roots life, and grants us the capacity to unfold gracefully while being content, quiet, and present. When yin is insufficient, we lack the qualities of receptivity and contemplation and become easily agitated, unsettled or nervously uneasy; the control over the dynamic manifestations of heat and activity is lost (Kaptchuk 1987). Yin represents the latent potential that awaits to be expressed and organized (Seem 1987).

Yang, by contrast, causes transformation and change, providing us with the capacity to engage life, to react, and to respond. Yang expands and disperses outwardly, granting the basic animating and invigorating quality of life that expresses our capacity to move, activ-ate, and transform. When yang is insufficient, we find ourselves para-lyzed in fear, confused and indecisive, unable to &press what we want, hopeless. When the quickening power to move is lost, the expression of life becomes soggy, congested, inactive, and frozen (Kaptchuk 1987).

Usually, we can detect in every person a relative vacuity of either the yin or yang roots of the kidney, which will affect in turn the rela-tive vacuity or repletion (hypoactivity or hyperactivity) of the associ-ated yin or yang viscera and bowels (Seem 1987). These tendencies, which can be both trait and circumstantial, will influence the manner in which an individual responds to his or her environment and the stressors therein.

When considering the human being as a smaller system living within a larger system, individuals’ relationships to their environ-ment become of the utmost importance in the development of illness. Each of us will experience an event and react to a stressor in a dif-ferent way. Our predisposition to develop a disorder at any given time depends on our individual experience of being in the world. Situations that create a conflict between our internal needs and desires and the demands placed upon us precipitate personal patterns of reaction based on our relative vacuity or repletion of either yin or yang (Seem 1987).

Based on this model, major depression can be considered as a `somatic energetic reaction pattern’ that is fueled by psychological and physical energies that are unique to the individual and that affect the experience of the disorder and nature of the symptoms. Moreover, this somatic energetic reaction pattern will influence the treatment protocol and prognosis. Stated differently, although persons with major depres-sion may share common symptoms, for each individual the dynamics of dysfunction would have developed in such a way that will require indi-vidualized treatment based on differential energetic diagnosis.

Fundamental Substances: Qi, Blood, Essence, Spirit, and Body Fluids

Qi

things; all physical and mental activities are manifestations of qi, and qi is perceived functionally by what it does (Beinfield & Korngold 1991). Sometimes referred to as ‘vital energy’ or simply ‘energy’, the concept of qi is much broader: qi is what motivates all movement, transformation, and change. According to Chinese Medicine, qi has five functions: defense, transformation, warming, restraint, and trans-portation. Qi protects the exterior of the body from invasion by exter-nal pathogens; it transforms substances so that they can be used by the organism; it provides warmth for the entire body; it holds the organs and substances in their proper place; and it propels all movement and transportation in the body.

Blood

According to Chinese Medicine blood is the substance that nourishes and moistens our body tissues. Blood is derived from food by the stomach and spleen, it is governed by the heart, stored in the liver, and moved through the vessels by the combined action of the heart and lung. When the blood is scanty or insufficient, no functions can take place; the blood moistens all body tissues, including the ligaments and tendons known as sinews in Chinese Medicine, as well as the skin and the eyes. Without proper nourishment and moisture, the tissues of the body can stiffen, dry out, and wither.

Blood and qi are very closely interrelated. In the human body, qi is the yang in relation to blood, which is the yin. The qi moves the blood, and the blood provides the material foundation for the qi. Blood, being yin in nature, provides nourishment and moistening, as well as the material foundation for the shen or spirit, which is yang. By accumulating in the heart, the blood helps to house and anchor the shen, and keep it rooted in the body (Schnyer & Flaws 1998). Later on, we will look in detail at some of the mental and emotional symptoms experienced during depres-sive episodes, which result from insufficiency or stagnation of blood.

Spirit

The Chinese concept of shen, or spirit, corresponds to the mental capac-ity to think, feel, and respond; it is what allows us to be conscious and alert during the day, and what becomes inactive during sleep. In that sense, shen refers to the Western concept of ‘mind’ (Wiseman & Feng 1998). In Chinese Medicine shen represents the accumulation of qi and blood in the heart; sufficient qi and blood accumulating in the heart are necessary to give rise to consciousness or spirit (Schnyer & Flaws 1998). Because shen is considered to have a material basis, its importance in medicine is not independent of the body. Kaptchuk (1983) refers to shen as the capacity of the mind to form ideas and the desire of the person-ality to live life. Human consciousness, memory, mental and emotional faculties, and awareness all indicate the presence of shen. For there to be consciousness and awareness, there needs to be sufficient qi; for the spirit to be quiet and calm, there needs to be enough blood to nourish it and settle it. Without sufficient blood (yin), the shen or spirit (yang) becomes restless; without enough qi our mental clarity is impeded (Schnyer & Flaws 1998).

Essence

Essence is the most fundamental, essential material the body utilizes for its growth, maturation, and reproduction (Schnyer & Flaws 1998). Essence determines the strength of the constitution. In women, the outward manifestation of essence is blood; in men it is semen. There are two forms of this essence: inherited essence, which is the constitutional basis acquired from our parents, and acquired essence, derived from the food and liquids we consume and the air we breathe. The natural process of living is the way in which we utilize this essence; we come to the world with a limited supply of inherited essence, our lifestyle choices determine the rate with which we use up this supply. Because all body functions depend on this essence, and because inherited essence cannot be replaced, it is very important to conserve it.

According to Chinese Medicine our inherited essence is a reservoir, and it is the acquired essence we create by eating, drinking, and breathing that provides the foundation for the qi and blood we utilize for our daily activities. If we eat properly, and through digestion we transform food and drink efficiently into nourishment (qi and blood), we produce sufficient qi and blood to perform our day-to-day activi-ties. If, in addition, we have a good night’s sleep, any surplus of qi and blood that was not utilized during the day goes on to bolster our inherited essence and become part of our reservoir (Schnyer & Flaws 1998). Inherited essence is governed and stored by the kidney; acquired essence is governed by the spleen.

This is, in part, the reason why digestion and diet are instrumental in understanding the mechanisms that underlie chronic and recurrent depression, why depression is more prevalent in women than in men (Kessler et al 1994), and why aging may be a risk factor in depression (Beekman et al 1999).

Body Fluids

The concept of body fluids comprises all the normal fluid substances of the human body; this term refers to fluids actually flowing within the human body, and to sweat, saliva, stomach juices, urine, and other fluids secreted or discharged by the body (Wiseman & Feng 1998). The body fluids are therefore different to the previous four concepts, as these fluids are the same as would be described in Western medicine. Body fluids in Chinese Medicine are differentiated as liquid fluids, which are thinner, mobile, and relatively yang in quality, and humor, which are thicker, less mobile, more turbid, yin fluids. The main function of the fluids is to keep the viscera and bowels, the skin, the hair, and the body orifices moistened; addition-ally, they lubricate the joints and nourish the brain, marrow and bones (Wiseman & Feng 1998).

The formation, distribution, and discharge of fluids involve complex processes in which several viscera and bowels play important roles. The processing of fluids begins in the stomach, where the useful part of the fluids (essential qi) is absorbed. The spleen carries this essential qi to the lungs, from where it is distributed to the other parts of the body. The small intestine separates the clear from the turbid, whereas the large intestine further absorbs fluid while conveying the waste material downward. Finally, the kidney plays the most impor-tant role in the formation and replacement of fluids by providing the warming and activating force for the other viscera and bowels to perform their roles; in addition, the kidney is responsible for trans-forming the surplus and waste fluid into urine, to be later discharged by the bladder.

The relationship between the concepts of viscera and bowels in Chinese Medicine and the organs as we know them in Western medicine is mostly of name and not of function. As mentioned above, the organs of Chinese Medicine represent a complete set of functions, both psychological and physiological, and are defined by their inter-action rather than by their anatomic structure. Each viscus and bowel has a responsibility for maintaining the physical and mental health of the organism. The viscera (relatively yin organs) store the essence and are responsible for creating and transforming qi and blood; the bowels (relatively yang organs) decompose food and convey waste. As mentioned above, there are five viscera — liver, heart, spleen, lung, and kidney (the pericardium is considered a sixth viscus in channel theory) — and six bowels: gall bladder, small intestine, stomach, large intestine, urinary bladder, and triple heater. The viscera and bowels are paired by functional relationship, respectively.

`The Liver holds the office of General of the armed forces. Assessment of circumstances and conception of plans stem from it.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallée 1985, p. 34)

The liver controls ‘coursing and discharge’, meaning that it regulates the smooth and unobstructed flow of qi and blood. The liver maintains the uninhibited and free movement of qi throughout the body in order to prevent stagnation.

According to Hammer (1990), the liver is the first line of emotional defense for the entire organism; when confronted by a noxious emotional stimulus, this energy system is the organism’s first choice for coping with the stressor. The liver deals with the stressors by assuring constant movement and circulation of qi, thus preventing stagnation.

The liver network expresses the capacity for growth, development, expression and change. Any experience that would inhibit this potential would directly affect the ability of the liver to maintain free flow. Any intense emotion that would find no release through verbal expression or physical activity would increase the demand on the nervous system for qi and blood, and would potentially render the liver incapable of renewing and circulating noxious energy (Hammer 1990). A condition of blockage or stagnation of qi would set in. Emotions, and especially anger and frustration, are the primary causes of liver qi stagnation.

Liver qi stagnation affects, in turn, other functions of the liver such as storing the blood and regulating digestion. It may also manifest as a blockage along the pathway of the liver channel (which traverses the pelvis, abdomen, chest, throat, gingiva, and head). Depending on the viability of the organ systems in a particular individual, liver depression qi stagnation may affect the functions of other viscera and bowels. The combination of liver depression with predisposing factors precipitates, in turn, the cascade of disease mechanisms that characterizes each distinct pattern of disharmony present during depression. We will explain further the concept of qi stagnation, its relationship to depression, its complications and ramifications.

Because the first effect of the emotions as causative factors of disease is to upset the liver’s function of coursing and discharge (i.e. the movement and transformation of qi and its proper circulation and direction), liver depression qi stagnation is likely to always be a significant factor in mental—emotional problems.

The term ‘liver depression qi stagnation’ is a technical one used in Chinese Medicine to denote a particular disease mechanism and pattern of disharmony that involves the liver and that implies qi stagnation due to emotional stress and frustration (Wiseman & Feng 1998).

`The Heart holds the office of Lord and Sovereign. The radiance of the spirits stems from it.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallee 1985, p. 23)

The heart is considered to be the emperor of the bodymind, the gov-ernor of the five viscera and the six bowels. The heart stores the shen or spirit, and is therefore considered to be the seat of consciousness and mental functions. If the heart is working normally, and qi and blood are abundant, the mind is lucid, alert, and responsive to the environment (Wiseman & Feng 1998 ).

Mental illnesses and emotional disorders in general affect the heart, but rather than originating in the heart itself, damage by the emotions begins in some other viscus or bowel eventually affecting the heart (Schnyer & Flaws 1998). All emotions affect the heart besides affecting their corresponding viscus or bowel (Maciocia 1994). Many of the symptoms characteristic of mental and emotional imbalance, such as sleep disturbances, incoherent speech, confusion and disorientation, anxiety and palpitations, correspond to an inability of the heart to perform the function of housing the shen. The heart’s ability to house the spirit can be affected by disease mechanisms that precipitate either vacuity or repletion patterns. When we refer throughout this manual to the concept of shen disturbance, we are referring to the different patterns that affect the heart’s function of housing the shen or spirit.

`The Spleen and Stomach are responsible for the storehouses and granaries. The five Wei (tastes) stem from them.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallee 1985, p. 64)

The spleen assimilates nutrients from food in the stomach to make qi, blood, and fluids; it governs the movement and transformation of food and water and the distribution of its essence (nutrients), playing a very important role in the creation of qi and blood. In Chinese Medicine it is said that the spleen is the source of qi and blood formation (Wiseman & Feng 1998), the source of engenderment and transformation (Schnyer & Flaws 1998). On the one hand, if the spleen becomes diseased it may not be able to create and transform sufficient qi and blood to nurture the heart and to provide mental clarity and awareness. On the other hand, if it fails in its function of moving and transforming body fluids, dampness may accumulate and lead to phlegm. Phlegm in Chinese Medicine denotes a viscous (yin) fluid that, when accumulated, may cause disease anywhere in the body; it may create a disturbance of the heart spirit and affect mental functions characterized by confused thinking, dullness of thought, brooding, and rumination.

`The Lung holds the office of Minister and Chancellor. The regulation of the life-giving network stems from it.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallee 1985, p. 30)

The lung is responsible for breathing and the production of qi; it moves and circulates the qi out to the edges of the body and from the top downwards. It assists the metabolism of body fluids by carrying water downwards to the bladder and preventing the accumulation of water in the body. In addition, the lung helps to protect the body from invasion by external pathogens. Like the heart, the lung is often affected by disease processes initiated in other viscera and bowels. For example, when liver qi stagnation affects the lung, it may create a sense of constriction in the chest, breathlessness, and a tendency to weep.

`The Kidneys are responsible for the creation of power. Skill and ability stem from them.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallee 1985, p. 76)

As we saw previously, the kidney as a single functional unit provides the basis for our congenital constitution; it stores the essence and holds the foundation for the yin and yang of all other viscera and bowels. The essential qi of the kidney is responsible not only for our reproductive capacity but also for the growth, development, and aging of the body (Wiseman & Feng 1998). In addition, any enduring disease damages the kidney, including mental and emotional problems. The harmonious relationship between the kidney and the heart is fundamental for the physical and mental wellbeing of the organism; these two viscera are interdependent and counterbalance each other. The kidney is the seat of the essence (jing), while the heart is the abode of the spirit (shen). Jing and shen, essence and spirit, soma and psyche, are aspects of a continuous process. Shen refers to the organizing force of the self, whereas jing refers to the material substance; together they refer to the totality of the human being (Beinfield & Korngold 1991).

`The Gall Bladder is responsible for what is just and exact. Determination and decision stem from it.’ (Su Wen, Ch. 8; cited in Larre & Rochat de la Vallée 1985, p. 43)

The main functions of the gall bladder are to secrete bile, which is formed from an excess of liver qi, and to govern decision. This last function implies that the capacity to maintain a balanced judgement in the face of adversity is attributed to this bowel; strong gall bladder qi ensures less vulnerability to external stimuli (Wiseman & Feng 1998), greater courage, and less timidity.

The gall bladder, however, plays a very important and somewhat peculiar role in the clinical treatment of mental—emotional disorders. This role is based on the relationship that the gall bladder has to the heart on the one hand, and to the liver on the other. The 11 organs are said to depend on the gall bladder and, therefore, if the qi of the gall bladder is strong, endogenous or exogenous pathogens cannot enter. These two statements link the gall bladder to the heart and its spirit, and elevate it to a place of greater importance (Schnyer Flaws 1998). The relationship between the heart and the gall bladder is further emphasized by a Chinese Medicine theory known as the `midday—midnight law’. This theory states that the circulation of qi along the channels is said to take its course over a period of 24 hours; according to this theory there is a special clinical relationship between viscera and bowels, which receive their maximal flow at opposite times of the day (Mann 1973). The heart has its maximal activity at 12 noon, while the gall bladder has its maximum activity at 12 mid-night.’ If the gall bladder is stimulated through acupuncture, the heart will be stimulated as well. It is interesting to note in this regard that several acupuncture points located on the gall bladder channel have a very profound effect on the treatment of mental—emotional conditions. Furthermore, the gall bladder is considered ‘the official residence of clear fluids’ (Flaws 1994) and it influences the transformation of body fluids. Therefore, points along the gall bladder channel are very effective in the treatment of patterns that involve accumulation of dampness and phlegm obstructing mental clarity, which are frequently found in depression. It is also worth mentioning that the guiding herbal prescription traditionally used to treat these type of patterns (phlegm dampness, obstruction, and stagnation, phlegm confounding the orifices of the heart, heart vacuity—gall bladder timidity, and phlegm fire harassing the heart) is known as `warm the gall bladder decoction’ (wen dan tang).

Also, the gall bladder stands as the yang counterpart of the liver. When qi (which is yang) accumulates, it becomes hot and tends to move in a yang direction: upwards. Therefore, stagnant liver qi com-monly moves into its paired yang channel, the gall bladder; symptoms of liver depression qi stagnation commonly appear along the course of the gall bladder channel as fullness, distension and lack of free flow (Schnyer & Flaws 1998 ).

Stomach

The stomach is the first to receive foods and liquids into the body; it is in the stomach that foods and liquids are first collected and are broken down to allow their nutrients to be absorbed. In complementary opposition to the spleen, which extracts the nutrients from food and sends them up to the lungs to be distributed, the stomach sends the food down to the intestines to be further absorbed and eliminated. In Chinese Medicine it is said that the spleen upbears the clear and the stomach downbears the turbid to explain this complementary relationship. Together with the spleen, the stomach has a pivotal role in the creation of qi and blood; many of the disease mechanisms respon-sible for depression due to insufficiency of qi and blood are a result of disturbance in the functions of both the stomach and the spleen. In repletion patterns it is very common to find stagnant liver qi attacking the stomach and upsetting its downbearing function, and for liver heat to collect in the stomach. Liver depression qi stagnation can render both the stomach and the spleen incapable of performing their respective functions. On the one hand the stomach becomes ‘dry and hot’ and cannot downbear the,turbid, while the spleen becomes ‘damp and weak’ and cannot upbear the clear. In addition, because the heart is said to be located above the stomach in Chinese Medicine and, because heat tends to rise, stomach heat counterflows upwards and agitates the heart (Schnyer & Flaws 1998).

Functions of the Viscera and Bowels and their Role in Depression

Depression, as well as any other mood disorder, can be a manifes-tation of an imbalance in certain functions of the viscera and bowels. Emotions are considered to be manifestations of qi that, if not expressed or transformed, become stagnant; they become a cause of disease only when they are experienced excessively or for a prolonged period of time, or both (Maciocia 1994). When the qi does not circulate properly, it becomes noxious and generates an imbalance.

Chinese Medicine does not separate physiological and psychological events; the shen or spirit is made by both qi and blood, which in turn are generated by the viscera and bowels. At the same time, the functions of the viscera and bowels, our qi, and our spirit are affected by external circumstances. In Schnyer & Flaws (1998), Bob Flaws explains it in this way: ‘the mind arises as a function of the viscera and bowels, but the functioning of the viscera and bowels is affected by the experiences of the mind and the emotions’ (p. 15). He goes on to say: ‘every thought or felt emotion is nothing other than the experience of the movement of qi … [C]hanging the way the qi moves, one changes one’s mental—emotional experience, while changing one’s mind and emotions changes the way the qi moves’ (p. 15).

The lung, spleen, and kidney (particularly the yang aspect of the kidney) are the viscera more directly involved in the production and transformation of our qi; the quality and quantity of qi depends on their functions. Therefore these viscera are most likely involved in patterns of depression due to vacuity of qi/yang or accumulation of dampness and phlegm. Owing to the role the liver plays in maintaining the free movement of qi (and blood), it will likely be involved in patterns resulting from qi stagnation, although the stag-nation may also directly affect the heart and lungs. The surplus of qi generated by liver depression qi stagnation can, over time, when severe or when combined with predisposing factors, create a predominance of yang (heat or fire). Yang repletion may accumulate in the liver, the heart or the stomach, and it may also consume yin, primarily of the liver, the kidney, and the heart. Liver depression qi stagnation may also progress into blood stasis, or it may generate accumulation of dampness or phlegm. Shen disturbance can be a result of either vacuity or repletion disease mechanisms that stem from dysfunction in other viscera and bowels; shen disturbance implies an imbalance in the heart’s function of housing the shen or spirit.

The most important viscera associated with the mechanism of depression are the liver, heart, and spleen; however, the kidney and lung also play important roles. The gall bladder and the stomach are the only two bowels that have special significance in depression. In brief, we will look at the role of each of these viscera and bowels in the precipitation of depressive episodes.

Acupuncture is said to adjust the density and flow of qi in the chan-nels and network vessels, which in turn affects the circulation of other vital substances (blood and body fluids) and the function of the viscera and bowels. Chinese medical theory, as it relates to acupuncture, encompasses five areas that provide the framework for assessment and treatment (Seem 1987). These areas are:

Eight guiding criteriaQi, blood, and body fluidsThe viscera and bowelsThe channels and network vesselsThe five phases.

Based on the training and style of the practitioner, one of these areas may be used primarily or several may be used in combination. We have explained in some detail some of the basic theoretical con-cepts that serve as the foundation for the aforementioned assessment areas. We now describe how the information gathered by examination is then organized using each one of these assessment areas as ‘filters’, through which we interpret the information.

The Eight Principles

The eight principles or eight guiding criteria are four sets of bipolar categories that help to differentiate and interpret the information gathered during examination (Beinfield & Korngold 1991). They serve as a conceptual matrix that enables the practitioner to organize the relationship between particular clinical signs and yin and yang (Kaptchuk 1983). Disease patterns can be identified by means of these eight fundamental principles: interior—exterior, cold—heat, vacuity—repletion and yin—yang. They determine the relative location, nature, and quality of the imbalance and constitute the basis of dif-ferential diagnosis from which the patterns of disharmony evolve. Interior and exterior describe depth of the disease; cold and heat describe the nature of the disease; vacuity and repletion describe the relative strength or weakness of one’s own right qi in relationship to pathogenic qi; yin and yang are the general categories that embrace the other six principles (Wiseman & Feng 1998). Interior, cold, and vacuity are yin features, whereas exterior, heat, and repletion are yang features. Each principle is associated with specific signs; by matching the patient’s signs the depth and nature of the diseases can be determined, as well as the relative strength of the.forces that resist the disease and those that cause it (Wiseman & Feng 1998).

Seem (1987) developed a phenomenological model that explains the mechanism for the development of vacuity and repletion patterns of either yin or yang, depending on one’s constitutional tendencies of `becoming hot’ (yang) or ‘becoming cold’ (yin). According to Seem’s model, we can interpret disease patterns as ‘somatic energetic reaction patterns’ that develop along one of two continua: yin deficiency—yang excess (hyperactivity and increased metabolic response) or yang deficiency—yin excess (hypoactivity, decreased metabolic response). In this view, when confronted with an emotional stressor or a perceived threat, the organism would tend to react in one of two ways: by activating sympathetic response in preparation for `fight or flight’ (yang) or by withdrawing from external activity and parasympathetically attending to internal demands and allowing the organism to ‘rest and digest’ (yin). If sympathetic activation is pro-longed, the organism exists in a chronic state of readiness, with the corresponding physiological reactions. Yang overtakes yin. If, on the other hand, the response is parasympathetic, the body will withdraw from action into a dependent stage, retreating from danger and looking for help. Yin overtakes yang (Seem 1987).6

We can use this interpretation of eight principles pattern differentiation to establish a parallel between these two reaction tendencies and the various symptoms of major depression. Each of the DSM-IV symptoms of major depression has corresponding symptoms of vacuity and repletion (deficiency/excess) of either yin or yang.

Qi, Blood, and Body Fluids

The mechanisms for the generation, transformation, and movement of qi, blood, and body fluids, which we explained above, are used as the conceptual matrix to understand the interactions and manifestations of yin and yang in the human body. Yin and yang are water and fire in the world, whereas qi and blood are fire and water in the body (Schnyer & Flaws 1998). As seen earlier, body fluids are also either yin or yang, depending on their function and nature. Essence and spirit also form a complementary yin and yang pair.

‘As we can see in Figure 3.1, if the yin of the kidney becomes situated on the left side of the five phases diagram, and the yang of the kidney on the right, when the yin of the kidney is vacuous or deficient ‘becoming hoe tendencies develop along the phases (and associated viscera) that are on the left; and ‘becoming cold’ tendencies due to yang vacuity develop along the phases (and viscera) on the right.

Clinically, when using qi, blood, and body fluids as a diagnostic filter, one determines the relative insufficiency or accumulation of qi and blood, the quality of generation, movement, and transformation of body fluids, and the condition and presence of the essence and spirit. In addition, the clinician evaluates the functional interactions between the viscera and bowels responsible with the production and movement of these ‘substances’. The use of qi, blood, and body fluids as a theoretical framework, in conjunction with the eight principles and the viscera and bowels, together constitute the foundation for TCM as a style of treatment.

Channels and Network Vessels

The network of channels in the human body is composed by four major systems: (1) the 12 regular channels, (2) the eight extraordinary vessels, (3) the secondary vessels, which include the tendinomuscular, connecting, and linking channels, and (4) the divergent channels. There are, in total, 71 channels (Seem 1990).

There are various approaches to using the channels and network vessels as a filter. For example, one may focus on knowing which level — defensive, nourishing, ancestral — is affected, in order to treat the corresponding network (Seem 1990). Alternatively, one may emphasize the treatment of the areas irrigated by the channels, as zones that are said to be structured and organized by the particular influence of each channel (Seem 1993). One may also use the concept of the six great units as constitutional diathesis (predisposition to disease) based on Yves Requena’s (1986) approach. The framework used throughout this manual incorporates these last two concepts: (1) the influence of the channels on different areas of the body when making our final point selection and (2) the six great units as consti-tutional diathesis, for understanding predisposition to the different pattern combinations.

The Channel System

The 12 Regular Channels

The 12 regular channels form the basic structure of the channel system and provide a network of qi and blood by which the whole body is nourished (Wiseman & Feng 1998). There are six yin and six yang channels, three of each on each hand and three of each on each foot. Each channel homes to viscera and bowels that stand in an interior—exterior (yin—yang) relationship. In addition to being paired by their internal—external relationship (yin—yang), the regular channels are also paired by the same polarity (yin or yang), with one arm channel and one leg channel to form the six great units; this results in a complex set of interactions that allow the acupuncturist to make subtle interventions to restore balance. Figure 3.2 lists the names of the 12 regular channels, their abbreviations, and their relationships.

The Eight Extraordinary Vessels

The eight extraordinary vessels are thought to develop prenatally before the development of the main channels; their function is to supplement insufficiencies of the other channels. The extraordinary channels do not home to any organs and do not have an interior—exterior relationship; they connect channels of the same polarity, whether yin or yang (Wiseman & Feng 1998). The extraordinary channels are du mai, ren mai, chong mai, dai mai, yang wei mai, yin wei mai, yang chao mai, and yin chao mai.

The Secondary Vessels

The secondary vessels include the tendinomuscular channels, the con-necting and the linking channels. The tendinomuscular channels run parallel to the regular channels on the surface of the body. The linking channels (luo) include 12 channels for each regular channel, plus one for du mai and one for ren mai. They extend the influence of the main channels to other parts of the body (Low 1983).

Two relationships between the channels are shown: in the right-hand column, the internal—external or yin—yang relationship is highlighted: one viscus and one bowel of the same phase are paired. On the left-hand side, the relationship that corresponds to the six units, between the upper and lower branches of each channel, is emphasized.This relationship underlines the correspondence between the viscus or bowel of one phase, with the viscus or bowel of a different phase.Adapted with kind permission from Seem ( 1987).

The Divergent Channels

The divergent channels leave the main channels at various points, but do not rejoin them; instead they join their coupled yang channel (Low 1983). They are considered of equal importance to the regular channels.

The channels are said to develop from conception through adult-hood; each channel level is said to carry a different kind of qi: defensive (wei), nourishing (ying), and ancestral (jing) (Seem 1990). The first to develop are three of the extraordinary vessels (du mai, ren mai, and chong mai; see below); then comes dai mai, followed by the remaining four extraordinary vessels. The second set of channels to develop are the tendinomuscular, followed by the regular, and finally the connecting, linking, and divergent pathways. For a summary of the different channel levels and their functions.

Channels and Network Vessels in the Treatment of Depression

In our protocol, we use primarily the regular channels because we are aiming at addressing dysfunction of the viscera and bowels. It is pos-sible, however, to develop a framework based on addressing the different channel levels mentioned above; it can be argued, for example, that depression is a stress response that should be treated initially at the level of the character armor (tendinomuscular level), or that one should aim at treating the core through the use of the extraordinary channels (Seem 1990). Clinically, it may be extremely useful to combine, in a progressive fashion, the use of the different levels. We hope to explore this possibility in the future. The present approach, however, involves solely outlining the rationale for the inclusion of some point combinations aimed at balancing two extraordinary channels, du mai and chong mai.

Du Mai

As summarized in this post, some studies conducted in China used points along du mai to treat symptoms associated with depression. Du mai, or the governing channel, plays a very important role in depres-sion. Du mai is one of the eight extraordinary channels and does not have a corresponding viscera or bowel. It emerges from the kidney; it is the storehouse of the yang, the sea of the yang channels, and has a regulating effect on the yang qi of the whole body. It begins its pathway at the perineum and ascends along the spine, up over the head and into the mouth. It is said in Chinese Medicine that the gov-erning vessel homes to the brain and nets the kidney. Since the kidney engenders the marrow and the brain is known as the ‘sea of marrow’, the governing vessel reflects the physiology and pathology of the brain and the spinal fluid, as well as their relationship to the reproductive organs (Wiseman & Feng 1998). The points along its pathway have been used traditionally, among other things, to affect mental func-tions. An excess of qi along the channel would mean an exuberance of yang: too much energy traveling ‘upward’ towards the head or stuck in the upper part of the body creating irritability, restlessness, and insomnia. An insufficiency in the flow of qi along its pathway will result in the inability of total yang of the organism to circulate, raise, and nourish the brain and spinal cord, manifesting as apathy, flat affect, and inability to express enthusiasm or emotion. The section on point indications provides greater detail on how we have used du mai in our protocol.

Chong Mai

Chong mai is where all the qi and blood of the 12 regular channels converge and it is considered to have a regulating effect on all of them (Wiseman & Feng 1998). The transportation and movement of the qi and blood of the whole body is focused on the chong, and therefore it is called the ‘sea of blood’ (Flaws 1997). The chong mai arises from the kidney and connects the liver with the pericardium (jueyin), bringing together the functions of menstruation (liver) and reproduction (kidney) with the heart’s function of housing the spirit. Chong mai is traditionally indicated in the treatment of menstrual and gynecological disorders, and it is broadly used to treat morning sickness during pregnancy.

In its pathway, the chong mai raises up through the regions irrigated by the liver and kidney (yin), connecting the peritoneum, the pleura, and the pericardium, and serving as the foundation upon which all the functions of the viscera and bowels develop (Seem 1990). The chong mai comprises the entire visceral cavity, and integrates the areas primarily affected by stagnation of liver qi.

The liver rules the area of the diaphragm and the region of the ribs. When confronted with a stressor, one commonly tightens up the diaphragm as well as the musculature of the chest and the upper back, the throat, the jaw, and the head. If this constriction of the diaphragm develops into a chronic stress response, the upper and lower regions of the body become ‘split’, as if one was cut off, so to speak, at the diaphragm, leaving the lower parts of the body vacuous and weak (kidney yang vacuity) and creating hyperactivity and agitation in the upper parts of the body (shen disturbance). In people experiencing depression, it is very common to find a constriction in the diaphragm, and neck and shoulder tension (liver qi stagnation), in combination with symptoms of decreased metabolic response on the one hand (kidney yang vacuity) and anxiety and agitation (yin vacuity—hyper-activity of yang) on the other. Chong mai allows us to integrate the complex relationship of patterns found in depression that involve the liver, the heart, the spleen, and the kidney simultaneously.

The Five Phases

The relationship between yin and yang is further differentiated into identifiable stages that describe the process of change between situations and across time. These stages — wood, fire, earth, metal, and water — are known as the five phases and reflect the transformation of yin into yang, and vice versa. Like yin and yang, the five phases are categories of quality and relationship (Wiseman & Feng 1998). Change is a process that takes place gradually as qi moves around the cycle represented by the five phases. According to the five phases theory, phenomena in the universe are the result of the movement and mutation of these five entities. Wood, fire, earth, metal, and water rep-resent certain qualities and relate to one another in specific ways; any other group of five phenomena that have qualities and relate to each other in similar ways are said to correspond to the five phases (Wiseman & Feng 1998;).

Yin, which expresses the potential of the bodymind (i.e. totality of soma and psyche), is characterized by water, and corresponds to the apparent quiescent stasis of the winter — a time when, beneath the surface, germination is preparing to bring forth the renewal of spring. It represents the capacity to store, generate, charge, and restore after release (Beinfield & Korngold 1991). Water is the moistening and descending to low places’ (p. 206); it corresponds to the blackness of the night, and with saltiness, the taste of sea water (Wiseman & Feng 1998).

Fire characterizes yang, the dynamic principle, the sense of splendor and fulfillment experienced when light, warmth, and interaction are at their peak. Fire symbolizes the end point of expansion and con-summation, of completion and fulfillment (Beinfield & Korngold 1991). ‘Fire is the flaming upward, and has the quality and upward movement’ (p. 205); it is associated with summer, with the color red, and the bitter taste (Wiseman & Feng 1998).

The transition of yin (the seed and the root) into yang (the flower and fruit) is represented by wood, an ascending movement of sudden growth and rapid expansion, of unexpected but unpredictable change (Beinfield & Korngold 1991). Wood is the bending and the straightening’ (p. 205), it grows upward and stretches outward; it corresponds to the spring, the time of growth and the beginning of the cycle of the seasons, it is associated with the green of new leaves in the sour taste of unripe fruit (Wiseman & Feng 1998). When the life force reaches its greatest expression, it begins to slow down, collapsing inward.

Metal represents the capacity for separation and refinement that is expressed in the autumn, when the energy contracts in order to consolidate, when the leaves fall and fertilize the soil for the next spring (Beinfield & Korngold 1991). ‘Metal is the working of change’ (p. 206), having the qualities of purification, elimination, and reform; it is associated with the white color of frost, and with the purifying action of acrid smelling things (Wiseman & Feng 1998).

These processes happen as we find ourselves on the earth, the point of reference that locates us in time and space. Earth represents our capacity for changing direction without losing balance, and is the axis around which other aspects orient themselves (Beinfield & Korngold 1991). ‘Earth is the sowing and reaping’ (p. 206), representing the planting and harvesting of crops and the bringing forth of phenomena. Earth is associated with yellow (the Chinese word includes brown), and with the sweetness of ripened fruit (Wiseman & Feng 1998).

Clinically, the five phases constitute a system for understanding the movement of qi through the five viscera; each of the five viscera corresponds to each of the five phases. Wiseman & Feng (1998) illustrate the relationship between the functions of the five viscera and the qualities of the five phases as follows:

`The liver controls the movement of qi around the body; it spreads qi just as the trees spread their branches; and as trees and other plants sprout upwards in the spring, so the liver yang tends to stir upwards. The heart has the function of propelling qi and blood to warm and nourish the whole body; it is like a fire that drives the body, just like the heat of summer makes nature flourish. The spleen is the source of qi and blood, that nourish and drive the body, just like the earth brings forth the crops at the end of the summer. The lung helps transform the fluids into blood, it controls the downward movement of the fluids to the kidney and bladder, and in this way is responsible for the purifying removal of waste fluids; it has the purifying qualities of the autumn frost. The kidney stores essence, just as nature preserves itself in winter dormancy.’ (Wiseman & Feng 1998, p. 206)

The five phases explain the etiology and nature of qi imbalances, providing in this way the framework for an energetic physiology to further comprehend the disturbances of the bodymind (Seem 1987). In addition to having similar qualities to one another, the phenomena associated with the five phases relate to other phenomena associated with the same phase in a similar fashion; for example, water engenders wood, and winter gives way to spring, and so the kidney (water) nourishes the liver (wood). Each phase corresponds to a set of channels and to a viscus and a bowel paired by their yin—yang relationship. (Each paired system is commonly identified by the name of the yin function: liver—wood, heart—fire, spleen—earth, metal—lung, water—kidney.)

According to Beinfield & Korngold (1991), every viscus and bowel has a responsibility or job to do, a strategy on how to do the job, and a character or way to do it, which reflects the nature of the energy represented by its pertaining phase. Every phase characteristically influences physiological and psychological functions that in turn correspond to the particular viscus (and bowel) associated with it. There is a corresponding tissue, sense, body fluid, sound, and smell associated with each phase. In addition there is an emotion and a mental aspect associated with each of the five phases. A more comprehensive description of the correspondence between the five phases, the five viscera, the emotions, and the mental aspects associated with each one of them is given in ‘The seven affects and the five emotions’ and ‘The five spirits’ sections below.

Correspondences of the five phases

In the context of the five phases, depression can be considered an imbalance in the movement of qi along the cycle of transformation of the energy. The five phases interact with one another according to pat-terns of generation and restraint which explain their capacity and provide the motivating impulse for their potential (Beinfield Korngold 1991). Illness is considered a process, not a static entity. When using the five phases as the basis for diagnosis and treatment, the system of correspondences is used to identify constitutional tendencies and to determine the configuration presented by the interaction of signs and symptoms, in order to attend to the root of the patient’s imbalance. Emotional disturbances are well explained using the theory of the five phases as a framework, which makes it an especially useful tool to understand distinct constitutional predispositions to depres-sion, to reframe the symptoms experienced by the person, and to develop a model for patient education.

As seen above, each of the five phases and its corresponding viscus has an associated emotion. These five emotions — anger, joy, worry, sadness, and fear — are considered to be manifestations of qi, basic forms of emotional activity; they become a cause of disease only when experienced excessively, for a prolonged period of time, or both (Maciocia 1994). Two emotions, anxiety or oppression, and fright, are added to these five to complement the gamete of human emotions; together they constitute the seven affects. Oppression reinforces other emotions such as sadness, obsessive thinking, or fear; it represents contraction, lack of circulation, immobilization (Larre & Rochat de la Vallée 1996); sometimes translated as anxiety (Wiseman & Feng 1998), this emotion is attributed to the lung or spleen, depending on the context (Larre & Rochat de la Vallee 1996). Commonly, fright refers to being startled with fright, and can mean any movement of the body, such as shaking or convulsions; it corresponds to the liver.

When disease originates from emotional causes it is known in Chinese Medicine as internal damage, affect damage, or damage by the emotions. (In Chinese Medicine, disease is said to originate from one of three causes: internal, external, or neutral (neither internal nor external). The emotions are said to be the internal causes of disease and are not to be confused with evils that arise internally such as internal fire or internal wind, which may develop from affect damage, but which can also be the result of insufficiency or transformation of external evils (Wiseman & Feng 1998).)

When the emotions are experienced persistently or intensely, they can alter the balance between yin and yang, blood and qi, and adversely affect the functions of the viscera and bowels. For example, whereas the liver, heart, and spleen seem to be involved most directly with the core symptoms of major depression, the interactions of these with other viscera and bowels can play a role in the appearance of other physical and psychological symptoms that may be seen during depression. These are symptoms for which depressed individuals may visit a physician, only to find no medical basis for their complaints. Because all symptoms, both physiological and psychological, are rele-vant in Chinese Medicine, these additional symptoms are equally important in determining the pattern of disharmony underlying depression. These symptoms help to establish the diagnosis and selec-tion of treatment principles and points.

For example, anger causes the qi to rise and can create distension and fullness in the rib cage and breasts, headaches, dizziness, and red, sore eyes; because the liver stores the blood, ascendant liver qi may carry the blood with it and cause nose bleeding. Because the liver and the spleen are closely related through the control cycle of the five phases, excessive liver qi moves across, ‘attacks’ and affects the spleen, making it incapable of performing its functions of transportation and transformation. A very common scenario encountered in depressive episodes is liver qi stagnation (frustration, irritability) in conjunction with a weak spleen, or spleen vacuity (weight changes, worry, abdominal distension); this weakness of spleen may, in turn, generate dampness or phlegm accumulation (yin repletion). Anger can also affect the stomach (nausea/vomiting), large intestine (irritable bowel), lungs (coughing and wheezing), and heart (agitation, insomnia).

Joy causes the qi to slacken; excessive joy leads to a dissipation of shen, or spirit, and a weakening of the heart qi, manifesting as heart palpitations, insomnia, and some mental diseases (Wiseman & Feng 1998) such as mania. Worry and overthinking cause the qi to bind, affecting movement and transportation and causing shallow breathing, fullness in the chest (lungs) and stomach, poor appetite, abdominal distension, and loose stools. They can also cause neck and shoulder stiffness (gall bladder, liver) (Maciocia 1994).

Sadness (grief) corresponds to the lungs. It causes the qi to disperse and can deplete lung qi, which manifests with a weak voice, breath-lessness, and weeping, or a feeling of constriction in the chest. According to Maciocia (1994), sadness may also affect the liver and create mental confusion, a lack of sense of direction, and an inability to plan; when held in for many years, it can affect the kidney and its regulation of fluid metabolism.

Incontinence or diarrhea may be caused by fear, which makes the qi descend and corresponds to the kidney. Fright, which in the summary above is associated with the heart, causes chaos and derangement of the qi, manifesting as disquietude of the spirit, and possibly more severe mental illness (Wiseman & Feng 1998).

Affect damage or damage by the emotions can originate from and/or give rise to vacuity or repletion patterns. Shen disturbance vacuity patterns manifest primarily as heart blood or heart yin vacuity, and to a lesser extent as heart qi vacuity; they generally stem from constitutional or circumstantial predisposition to qi and blood vacuity. Shen disturbance repletion patterns stem from either liver depression or spleen and kidney vacuity. -When originating from liver depression, they manifest as qi stagnation affecting the heart, depres-sive heart agitating the spirit, or blood stasis blocking the heart’s orifices; when stemming from spleen and kidney vacuity, they manifest as variety of patterns that derive from phlegm obstructing the orifices of the heart.

The Five Spirits: Five Mental Aspects of the Bodymind

In addition to the spirit (shen), which is stored by the heart, each yin viscus houses a specific mental aspect of the human mind. The shen itself indicates consciousness and memory; it maintains our awareness and expresses the integration of our being. The liver stores the hun, usually translated as the ethereal soul. The hun is said to complement the functions of the shen, and it is related to intuition and inspiration, insight and courage. The hun gives us a sense of direction and the capacity for planning; it influences sleep and dreaming. In the spleen is stored the yi or reflection, which represents our verbally expressed thoughts, our capacity for applied thinking, studying, memorizing, focusing, concentrating, and generating ideas. The kidney stores the zhi, which corresponds to will, drive, and determination; it also pro-vides us with the capacity to store information and is related to long-term memory. The po or corporeal soul is stored in the lung and is what gives the body its capacity for movement, physical sensation, and coordination. It can be linked to the physical expression of the hun or to the organizational principle of the body, and it is considered to be closely related to the essence, considered the foundation of human life.

Depending on the specific manifestations, severity, and precipitating factors in a depressive episode, one or more of these mental aspects will be affected.

The Five Virtues and other Correspondences of the Five Phases

Any human quality, mental attribution, or emotional experience can be attributed to the five phases. For example, each of the five spirits has a primary responsibility for a particular virtue (Kaptchuk 2000). Shen, which resides in the heart and corresponds to fire, is responsible for ceremony and propriety (li). ‘Propriety ensures that correct behavior fosters timely interactions and relationships’ (Kaptchuk 2000, p. 64). Hun, which resides in the liver and corresponds to wood, is responsi-ble for human kindness and benevolence (ren): ‘it has an intimate rela-tionship to a person’s capacity to feel and endure pain’ (Kaptchuk 2000, p. 61). In the spleen resides the yi, which corresponds to earth and is responsible for ‘faithfulness, loyalty or sincerity (xin) and has the task of enabling and supporting new manifestations to come into being’ (Kaptchuk 2000, p. 60). Zhi, which resides in the kidneys and corresponds to water, is responsible for the virtue of wisdom (zhi): ‘a knowing that has to do with learning to have a relationship to what is unknown and what is unknowable … a deep trust that the unknown eventually reveals an inevitable destiny’ (Kaptchuk 2000, p. 62-63). In the lungs, which correspond to metal, resides the po. The po is respon-sible for the virtue of preciousness (bao). ‘The Po is said to capture the perfection and completeness of a single moment or a short time span’ (Kaptchuk 2000, p. 65).

In Chinese Medicine, virtue refers to impulse from which all things manifest through the movement of qi (Larre & Rochat de la Vallée 1995). In the Ling Shu, it is said: ‘Heaven in me is Virtue. Earth in me is Breaths. Virtue flows, Breaths spread out, and there is Life’ (Larre & Rochat de la Vallée 1991a, p. 87). In the human being, `virtue is the authenticity of the heart as it moves along’, ‘through virtue one both finds and possesses oneself, and ‘virtue gives authen-ticity to the one that possesses virtue’ (Larre & Rochat de la Vallee 1995). For a more complete interpretation of the five phases, their correspondences, and their clinical application, refer to the numerous books of Claude Larre & Elisabeth Rochat de la Vallée, such as The Seven Emotions and Rooted in Spirit, and to Harriette Beinfield & Efrem Korngold’s Between Heaven and Earth and to Lonny S. Jarrett’s Nourishing Destiny.

dimanche 20 octobre 2013

Cancer Risk Assessment, Screening and Prevention

Nearly everyone will encounter cancer at some time in their lives, either through a personal diagnosis or the diagnosis of a relative or friend. Cancer is a common disease, with about 1.4 million new cases diagnosed each year in the United States alone. In fact, cancer has recently overtaken cardiovascular disease as the leading cause of death for Americans under the age of eighty-five, and it accounts for twice as many deaths as cardiovascular disease in those under sixty-five. Over a half million Americans die of cancer each year. This figure corresponds to more than 1,500 cancer deaths each day, or approximately 1 death per minute. Figure 1 shows the five leading sites of cancer incidence and their corresponding death rates in men and women.

Despite these numbers, there is reason for optimism. Even with increases in the American population, the rate of new cancer cases and deaths for all cancers combined dropped for the first time since record keeping began in the 1930s. Death rates from cancer have decreased each year from 1993 to 2002, the most recent year for which full data is available. Advances in prevention, early detection, and treatment have helped reduce death from cancer. More than 10 million people alive today with a history of cancer can attest to recent successes.

Thousands of scientists, doctors, nurses, patients, volunteers, and others have devoted themselves to conquering cancer. Their efforts have increased survival rates for all cancers combined to over 60 percent. New approaches are vital in reducing cancer incidence and deaths. New procedures are being developed to detect cancers in early and treatable stages. Genetic research and studies of the immune system continue to seek answers to why cancer cells have uncontrolled growth. New drugs attack cancer cells at specific points in their developmental pathway, before the cells become cancerous. These and future advances will one day cure cancer.

More immediate progress against cancer can be made in the areas of prevention and early detection. To achieve these goals, we must recognize that risks can be identified and reduced; tests can detect cancer in its earliest, most treatable stages; and many cancers can be prevented altogether by modifying our lifestyles.

Risk Factors

Risk factors are personal characteristics or events that may affect that person’s chance of developing a disease. Lifestyle, environment, and genetic makeup, alone or in combination, help determine cancer risk.

When thinking about cancer, it is sometimes useful to think of a risk factor as something that can cause insults, or “hits,” to the genetic structure of a normal cell. These hits cause normal cells to change to cancer cells by interacting with and altering a gene’s normal DNA and protein products. Cancer is an accumulation of these alterations, or mutations, that result from multiple events acting together over many years or decades. It is not a one-step, one-hit process.

Certain risk factors have been identified as causing hits that start a normal cell’s journey toward becoming a cancer cell. These risk factors hits include tobacco, X-rays, sunlight, industrial chemicals, some types of hormones and drugs, and certain viruses. Other hits promote the cell’s continued progression to cancer; alcohol and high-fat diets are associated with these hits. It may take several promoting hits to damage a cell beyond repair and mutate its DNA. As hits and mutations accumulate, the cell starts to grow uncontrollably, eventually becoming a cancer cell.

On the positive side, the human body does a remarkable job of protecting itself from cancer. Our cells are exposed to potential cancer-causing compounds (carcinogens) every minute of every day. Many of these compounds are by-products of normal body metabolism. The body has several lines of defense against these carcinogens, including mechanisms to protect DNA and to repair any DNA damage that occurs. Additionally, the body can alter the cell’s environment to make it more difficult for an already cancerous cell to grow in an uncontrolled fashion.

Risk factors can be classified as modifiable or nonmodifiable. We can do nothing about nonmodifiable risk factors, such as our gender, our race, our genes, and the hormones that are naturally produced by our bodies. But modifiable risk factors are risk factors that we can choose to change.

Nonmodifiable Risk Factors

Gender, Ethnicity, and Race Some of the gender differences for cancer are obvious. For example, the risk of breast cancer is approximately 100 times higher in women than in men. However, men are not entirely immune from this disease: Estimates suggest that more than 2,000 men in the United States will develop breast cancer in 2007. Similarly, race and ethnicity can have a significant impact on cancer risk. African-American men, for instance, are more likely to develop prostate cancer and often develop this cancer at an earlier age than men of other races. Individuals of Ashkenazic-Jewish descent have higher rates of mutations in breast cancer susceptibility genes such as BRCA1 and BRCA2. Many researchers are trying to improve our understanding of cancer risks in different populations so that prevention efforts can be tailored to meet these needs.

Heredity When the same types of cancer appear in a family for generation after generation, a genetic alteration (inherited from the father or the mother) may be the first damaging hit to the DNA that begins the cell’s change to cancer. Usually, other hits are required to sustain the cell’s progression to a tumor. Approximately 10 percent of all cancers result from hereditary predisposition. Most cancers are not hereditary in nature and result from a complex interaction of genes, environment, and lifestyle.

Hormones Produced by the Body One of the most important risk factors for developing breast cancer is a woman’s lifelong exposure to naturally occurring hormones. The longer a woman produces hormones, the more likely she is to develop breast cancer. Factors such as early menstruation (before age twelve) and late menopause (after age fifty-five) contribute to prolonged hormone exposure. The number of ovulatory cycles in a woman’s lifetime can also affect her risk of cancer. Women who have an increased number of uninterrupted ovulations have been shown to be more likely to develop ovarian cancer. This phenomenon may explain why events that interrupt ovulatory cycles, such as pregnancy, breast-feeding, and oral contraceptive use, are associated with a decreased risk of ovarian cancer.

Modifiable Risk Factors

Tobacco It is estimated that there are approximately 45 million current smokers and more than 46 million former smokers in the United States. All of these people are at increased risk for developing cancer. Tobacco use is the single most preventable cause of death in the United States. Cigarette smoking is directly responsible for at least 30 percent of all cancer deaths each year. Smoking also causes chronic lung disease, heart disease, stroke, and vascular disease.

More than 3,000 chemicals are present in tobacco smoke, including at least 60 known carcinogens. Some of these chemicals become carcinogenic only after they are activated by specific enzymes (proteins that control chemical reactions) found in many tissues in the body. These activated compounds can then mutate DNA and interfere with the normal growth of cells. Tobacco also contains nicotine, a chemical that causes physical addiction to smoking. During smoking, nicotine is absorbed quickly into the bloodstream and travels to the brain, causing the addictive effect.

Since the release in 1964 of the first surgeon general’s report on smoking and health, the scientific knowledge about the health consequences of tobacco use has greatly increased. It is now well documented that cancers of the lung, larynx, esophagus, mouth, and bladder are caused by smoking. Cigarette smoking is the most important risk factor for lung cancer, accounting for 68 to 78 percent of lung cancer deaths among females and 88 to 91 percent of lung cancer deaths among males. Additionally, smoking is known to contribute to cancer of the colon, stomach, cervix, pancreas, and kidneys.

Many people are under the impression that cigars and smokeless tobacco are safer alternatives to cigarettes. Considerable evidence shows that smokeless tobacco and cigars also have deadly consequences, including lung, larynx, esophageal, and oral cancers. Smokeless tobacco—chewing tobacco and dipping snuff—contains at least twenty-eight carcinogens. Habitual use of these products threatens the lives of several million Americans.

Children, too, are not spared addiction to tobacco. About 3 million adolescents report smoking at least once in the last month; 1.1 million report daily smoking. Nearly 4,000 young people begin smoking each day, and over 6 million people who decided to begin smoking as children will die early, preventable deaths. Clove cigarettes and flavored cigarettes are ideal “training cigarettes” for people in this age group; however, rather than being safer alternatives to regular cigarettes, these products are often unfiltered and have the same or greater health risks.

The risk of developing lung cancer, as well as other smoking-associated diseases, depends on an individual’s total lifetime exposure to cigarette smoke. Such exposure is measured by the number of cigarettes a person smokes each day, the age at which smoking began, and the number of years a person has smoked. For example, in those who smoke forty or more cigarettes a day (two or more packs), the risk of death from lung cancer is more than twenty times the risk in nonsmokers.

The harmful effects of smoking do not end with the smoker. Each year, exposure to secondhand smoke, also known as environmental tobacco smoke (ETS), causes an estimated 3,400 nonsmoking Americans to die of lung cancer. ETS has also been significantly linked with nasal sinus cancer in nonsmoking adults. The surgeon general has recently issued a report that states that there is no safe level of secondhand smoke.

Quitting smoking is a critical step toward improving health. Methods and resources that can aid in quitting can be found in “How Can You Reduce Cancer Risk?” in this post.

Diet and Nutrition Scientific studies suggest that about 30 percent of all cancer deaths are associated with poor dietary and nutrition practices. Specific risk factors include certain types of foods; methods of cooking, processing, and storage; and excessive caloric intake of food.

Substantial evidence shows that fats and alcohol are two dietary components that, when used imprudently, can increase cancer risk. Excessive dietary fats appear to play a role in the development of cancers at multiple different sites, including the breast, pancreas, endometrium (uterus), esophagus, and colon. Although saturated fats (derived mainly from animal sources) were considered the primary culprit in the past, both saturated fats and unsaturated fats have been associated with increased cancer incidence. Similarly, overuse of alcohol has been shown to contribute to breast, colorectal, head and neck, esophagus, and liver cancers. Risk increases with the amount of alcohol consumed and may start to rise with as few as two drinks per day. Many of the by-products of alcohol are recognized carcinogens.

Just as foods are a source for potentially dangerous carcinogens, so diet plays a role in protecting us from cancer. Populations that consume large amounts of plant-derived foods have decreased incidence of certain types of cancers, including those of the esophagus, mouth, stomach, colon, rectum, lung, and prostate. Fiber, fruit, and vegetable intake have been studied to determine their effects on colon cancer risk. Clinical trials that emphasized intake of these foods did not show a decreased rate of recurrence for colon polyps, which are considered precursor lesions for colon cancer. However, these results may be due to following the special diets for too short a time to have an effect. Intake of fiber, fruits, and vegetables is still strongly encouraged due to the other health benefits from these foods. Some of the main results from these studies are summarized in Table 1.

Table 1. Selected Large Dietary Intervention Trials for Cancer Prevention9% reduction in breast cancer risk (nonsignificant)Participants did not achieve the low-fat goal; may not have had long enough follow-up period to detect a difference.8% reduction in colon cancer risk (nonsignificant); mild reduction in colon polypsParticipants did not achieve the low-fat goal; may not have had long enough follow-up period to detect a difference.Women’s Intervention Nutrition Study24% reduction in risk of breast cancer recurrenceMay be useful for women with tumors that are negative for estrogen receptors.No difference in risk of recurrence; trend toward reduction of risk in menMay not have had a long enough follow-up period to detect a difference.24% reduction in risk of breast cancer recurrence4% reduction with dietary changes (nonsignificant); trend toward reduction in menMay not have had a long enough follow-up period to detect a difference.

Levels of micronutrients may also play a role in determining cancer risk. People with higher levels of the micronutrient selenium have been found to have fewer deaths from lung, colorectal, and prostate cancers. Large studies are currently taking place to determine if selenium supplements can prevent these cancers from occurring.

Studies have shown that daily consumption of red meat may double the risk of colon cancer. One explanation for this finding may be the methods used to cook or prepare the meat. Processed meats that are salt-cured, salt-pickled, or smoked have been associated with increased risk of gastric cancer, whereas meats that have been broiled or grilled at high temperatures have been shown to have increased levels of carcinogens that can increase colon cancer risk.

Other nutrition-related factors such as obesity and physical activity are part of the complex interaction of lifestyle choices that affect cancer risk. Regular physical activity seems to protect against cancer in the breast and colon, reducing risk by as much as 50 percent. Obesity has the opposite effect, increasing levels of hormones and other substances that encourage continued growth of cancer cells. For example, large fat deposits may be responsible for converting estrogen precursors to high levels of circulating estrogens. Unfortunately, current trends show that Americans are increasing their caloric intake, eating more high-fat convenience foods, and being less physically active. These trends may be related to more frequent meals away from home, sedentary lifestyle patterns, and increased media promotion of high-calorie foods.

Exposure to Sunlight Nonmelanoma skin cancer is the most common malignancy in the United States, representing 40 percent of all cancers. During the past thirty years, all types of skin cancers—melanoma, basal cell carcinoma, and squamous cell carcinoma—have increased dramatically. These skin cancers are caused primarily by overexposure to the sun’s ultraviolet rays.

Solar rays can damage skin even on cloudy days. With the continued thinning of the protective ozone layer, damaging rays are becoming more intense and dangerous. Over the short term, excessive sun exposure causes freckling, sunburn, and tanning, all of which are forms of skin damage. Rather than being a sign of good health, a tan signals the skin’s attempt to defend itself against solar radiation. Over longer periods of time, high levels of sun exposure can cause premature skin aging, wrinkles, and rough leathery skin, in addition to skin cancers.

Research findings suggest that intermittent intense sun exposure may increase the risk of malignant melanoma, the deadliest form of skin cancer. A history of five or more blistering sunburns can double the risk of melanoma. Because we accumulate much of our lifetime exposure to the sun prior to age eighteen, it is especially important to protect infants and children from sun overexposure.

Artificial sources of sunlight, including sunlamps and tanning booths, also increase the risk of developing skin cancer. Unfortunately, skin damage from any form of ultraviolet light is permanent and accumulates over a lifetime; however, it can be minimized by limiting sun exposure.

Geographic Patterns and Environmental Exposure The geographic patterns of cancer may provide important clues to the causes of cancer. Possible geographic risk factors include occupational exposures, regional dietary habits, ethnic background, and environmental exposures from the air or water. Additionally, geographic differences in mortality rates may reflect differences in access to medical care, such as screening, diagnosis, and treatment facilities.

Workplace exposure to chemicals such as coal-tar-based products, benzene, cadmium, uranium, asbestos, and nickel can greatly increase the risk of developing cancer. Up to 20 percent of bladder cancers may be due to chemical exposures in the aluminum, dye, paint, petroleum, rubber, and textile industries. Occupational exposures to radon and asbestos have been linked to lung cancer, and 1 to 2 percent of lung cancer deaths are attributable to air pollution.

Fertility Drugs and Oral Contraceptives Use of fertility drugs has been associated with an increased risk of ovarian cancer in some studies. However, infertility itself also increases ovarian cancer risk, thereby making it difficult to assess the independent risk associated with fertility drugs. The duration of use for some fertility drugs is restricted in order to prevent additional increases in ovarian cancer risk. Endometrial cancer is also increased in women who take fertility drugs, although separating the effect of the drugs from that of the infertility can be difficult in this case as well. Fertility drugs are not thought to increase the risk of breast cancer, cervical cancer, or colon cancer, although information in this area is somewhat limited.

The relationship between oral contraceptives and cancer risk has been controversial. Studies investigating the role of oral contraceptives on breast cancer risk have had conflicting results, but the majority of the evidence suggests that there is no increased risk of breast cancer in users of oral contraceptives. Ovarian cancer risk is decreased in oral contraceptive users in the general population, but the results are unclear for those who have an increased risk of ovarian cancer due to genetic susceptibility. Use of these medications has been shown to decrease the risk of endometrial cancer as well.

Hormone Replacement Therapy (HRT) For years, hormone replacement therapy, consisting of estrogen alone or in combination with progesterone, has been an option for women when they reach menopause. Potential benefits of hormone replacement therapy in postmenopausal women include protection of the bones from osteoporosis (bone thinning) and relief from menopausal symptoms such as hot flashes, vaginal dryness, insomnia, and mood changes. HRT was thought to have beneficial effects against heart disease as well; however, more recent evidence now indicates that heart disease is not decreased with the use of these medications.

Initially, hormone replacement therapy was the only tool that was available to treat these conditions. In recent years, newer drugs such as raloxifene (Evista) and alendronate (Fosamax) have become available to reduce the risk of fracture in those suffering from osteoporosis. These drugs are from a different class of medication than hormone replacement therapy and protect the bones in a different way. Nonhormonal therapies are also available to improve symptoms of hot flashes, insomnia, and mood changes.

Hormone replacement with estrogen alone has been shown to increase the risk of endometrial (uterus) cancer in women who have not had a hysterectomy. In the 1970s, women who received estrogen without progesterone were six to eight times more likely to develop endometrial cancer than women who were not on this medication. Since that time, doctors have prescribed HRT that includes low-dose estrogen and progesterone for women who have not had a hysterectomy. Progesterone counteracts estrogen’s negative effect on the uterus by preventing the overgrowth of the endometrial lining, thereby reducing the risk of endometrial cancer associated with taking estrogen alone. However, the addition of progesterone to estrogen replacement therapy dramatically increases the risk of breast cancer, as discussed below. A woman who has had a hysterectomy does not need progesterone and can receive HRT with estrogen alone.

Over the past thirty years, considerable research has examined the question of whether HRT affects breast cancer risk. The research falls into two categories: observational studies, which investigate differences in cancer rates in women who are already taking HRT as compared to those who are not; and clinical trials, which randomly assign women to use HRT or to use a placebo. Because observational studies may not account for all of the differences between women who use HRT and women who do not, clinical trials are considered to provide the strongest evidence.

Some of the early studies indicated that women who used high doses of estrogen alone had an increased incidence of breast cancer. More recently, analysis of data from the Nurses’ Health Study, an important large observational study comparing women who take hormone replacement therapy with those who do not, showed that prolonged use of estrogen increased the risk of breast cancer. After fifteen years of estrogen replacement, women had a 48 percent increased risk of hormone-sensitive breast cancer. After twenty years of replacement, there was a 42 percent increased risk in all types of breast cancer.

Other studies have shown that progesterone replacement may significantly increase the risk of breast cancer. One of the most important clinical trials in this area, the Women’s Health Initiative, was designed to test the effects of hormone replacement therapy on heart disease, breast cancer, and colorectal cancer risks. Over 26,000 postmenopausal women were enrolled in 1991 and randomly assigned to hormone replacement or placebo. Women who had previously undergone hysterectomy were given estrogen alone or a placebo, and women who still had a uterus were given an estrogen-progesterone combination or a placebo. Results from this study showed that the combination of estrogen and progesterone was associated with an increased risk of breast cancer and a decreased risk of colorectal cancer. The women who took estrogen only did not have a decreased risk of colorectal cancer, and the effect on breast cancer risk was uncertain.

Combination HRT with estrogen and progestin has been shown to increase breast density, as seen on mammograms. Studies have shown that women ages forty-five and older whose mammograms show at least 75 percent dense tissue are at increased risk for breast cancer. Increased breast density makes it more difficult to interpret mammograms; and follow-up procedures must sometimes be done, including mammograms, ultrasounds, and biopsies. The Women’s Health Initiative found that women who took estrogen alone also required increased numbers of mammograms.

Use of hormone replacement therapy in women who have a history of breast cancer or endometrial cancer remains controversial. At present, the standard of care is to use medications other than hormone replacement to treat menopausal symptoms and prevent osteoporosis in these women. Only in the most extreme situation of uncontrolled, severe hot flashes should estrogen replacement therapy be considered in this setting.

Sexual Activity Cervical cancer is caused by infection with a sexually transmitted virus called the human papillomavirus (HPV). Although most women are exposed to this virus in their lifetime, infection is usually transient. When this virus cannot be cleared by the body, cervical cancer may develop. Individuals who have multiple sexual partners or have a compromised immune system are more susceptible to the virus for this reason. HPV is also thought to play a role in cancers of the penis, vagina, and anus.

Risk Assessment

Just by virtue of becoming older, we all develop some risk for cancer. However, some people may be at even greater risk because of their combinations of modifiable and nonmodifiable risk factors. Individuals with a cancer risk that is three to five times that of the general population are considered at high risk. To identify people at high risk for cancer, risk assessment programs have been developed at many cancer centers. To enter a program, the participant completes a questionnaire that asks detailed questions about life history, personal and family medical history, work history, and lifestyle habits. A physical examination, blood work, and imaging studies may be part of the assessment as well. The questionnaire responses are analyzed to produce cancer risk scores, which are then interpreted. Participants receive results of the assessment, along with risk-reduction recommendations. These results are often forwarded to the participant’s primary care provider as well.

Some risk assessment questionnaires focus on specific types of cancer and ask specific questions to determine how well an individual fits in a specific model of cancer risk. One of the best-known models is the Gail model, which predicts breast cancer risk based on race, current age, age when menstruation began, age of first live birth, number of close relatives with breast cancer, number of breast biopsies, and the presence or absence of changes called atypical hyperplasia on breast biopsies. Most of these models have limitations (for example, the Gail model does not ask about ovarian cancer history or breast cancer history in second-degree relatives such as aunts, cousins, or grandparents; it may also be less accurate in predicting risk in non-Caucasian women). Therefore, models should be selected based on each individual’s situation in order to calculate risk as accurately as possible.

Several cancer risk assessment programs are available off the Internet. These programs may be less comprehensive than those available from cancer centers. Additionally, these programs cannot always answer questions you may have or individualize recommendations to your particular case. When using on-line programs, be sure to verify recommendations with your health care provider.

Hereditary Risk All cancers have a genetic component; the hallmark of all cancers is genetic instability. Although most cancers are sporadic (not inherited), about 10 percent occur because of hereditary predisposition. All men and women are born with cancer susceptibility genes, such as the breast cancer susceptibility genes BRCA1 and BRCA2. However, only people with alterations in cancer susceptibility genes are at higher genetic predisposition for cancer. Table 2 summarizes established risk factors for hereditary cancers and syndromes. Figure 3 illustrates a family pattern of breast cancer that is consistent with an inherited genetic predisposition.

Table 2. Established Risk Factors for Hereditary Cancers and Cancer Syndromes• Two or more first-degree relatives (parent, child, or siblings) with a specific cancer or cancers. These individuals can be on the mother’s and/or father’s side of the family.• One first-degree and two or more second-degree relatives (grandparents, aunts, uncles, grandchildren) with a specific cancer or cancers.• Evidence of transmission of cancer from generation to generation.• Unusually early age of cancer onset.• Clustering of the same types of cancers in close relatives.• Family members with cancer in paired organs (both breasts, both kidneys, both eyes).• Geographical heritage and ethnicity.

Genetic alterations associated with inherited predisposition to cancer can be identified through analysis of a blood or tissue sample. At this time, genetic testing is recommended only for individuals who have a personal or family history suggestive of an inherited cancer syndrome. The most effective way to determine if a heritable genetic alteration is in a family is by testing the individual who has had the cancer that fits the hereditary pattern. If a genetic alteration is identified in the individual who has had cancer, other individuals in the family who are at risk can be tested for the mutation identified in their family member. Genetic analysis should always be preceded by careful genetic counseling, which continues after determining gene mutation status. Identification of a genetic alteration may change recommendations for cancer screening, and chemoprevention medications or surgery options may be appropriate for these individuals.

Some genetic testing kits have become directly available to consumers. However, the implications of finding or not finding a genetic mutation can be profound. We do not recommend undertaking such testing without appropriate counseling from a professional with training and expertise in this area.

Screening and Early-Detection Guidelines

Despite all the advances in cancer treatment, the approach most likely to decrease cancer deaths is early detection. Catching cancer at its earliest stages can prevent spread to distant sites, which is the cause of most cancer deaths. Early detection depends on recognizing cancer’s warning signals and receiving prompt medical attention when signs and symptoms appear. The cornerstones of early detection are self-examination, examination by a health professional, and screening tests.

Self-Examination Breast self-examination was previously recommended for all women by the American Cancer Society. The most recent recommendations state that the risks and benefits of self-examination should be discussed with women, and that performing self-examinations infrequently or not at all is acceptable. This recommendation has been changed due to research that demonstrated no decrease in breast cancer deaths in women who performed breast self-examinations compared to women who did not. However, many clinicians still recommend breast self-examination because it promotes awareness of the breast, helps find breast changes early on, and has no cost. Women who perform this examination should be trained by a health professional.

Likewise, testicular self-examination is not formally recommended by the American Cancer Society. However, it also promotes awareness, helps find changes early on, and has no cost. Although testicular cancer is uncommon overall, it is one of the most common cancers in men ages twenty to thirty-five. Testicular cancer is highly curable when detected early.

Skin self-examination is another important component of health that is often overlooked. Men and women are encouraged to become familiar with their skin, including any freckles or moles. A mole that is asymmetric, has an irregular border, is more than one color, or is larger than the size of a pencil eraser should be evaluated by a dermatologist. In addition, any new skin lesions or changes in an existing mole or freckle should also be reported right away.

Clinical Examinations and Screening Tests Screening guidelines for any type of cancer depend on two primary factors: the age of the individual undergoing screening, and the individual’s risk factor profile. Risk factors can be due to lifestyle, family history, or other medical conditions. Table 3 summarizes the American Cancer Society recommendations for cancer screening for individuals at average risk of cancer. In the discussion below we will highlight some of the details behind the screening recommendations and note where controversies currently exist.

Table 3. American Cancer Society Recommendations for the Early Detection of Cancer in Average-Risk Asymptomatic PeopleWomen ages 20–39 Women ages 40 and overEvery 3 years Every year (to be done prior to mammogram)Every year (conventional Pap test) Every 2 years (liquid-based Pap test)• Pap test every 2–3 years (either type)• Pap test + HPV (human papillomavirus) testing every 3 yearsIf one or more of last 3 tests were not normal, follow guidelines for ages 18–30.Women who have had total hysterectomyMay choose to stop screening if 3 normal Pap tests and no abnormal tests in 10 yearsProstate-specific antigen (PSA) blood test and digital rectal examinationMen ages 50 and over with life expectancy of at least 10 yearsColorectal cancer screening (any of the following procedures):Men and women ages 50 and over• Fecal occult blood test**** or fecal immunochemical test, OREvery 5 years, starting at age 50• Fecal occult blood test and flexible sigmoidoscopy, ORFecal occult blood testing every year with sigmoidoscopy every 5 years starting at age 50• Double contrast barium enema, OREvery 5 years, starting at age 50Every 10 years, starting at age 50* Women should be informed of the benefits and limitations of breast self-examination (BSE). It is considered acceptable for women to choose not to do BSE or to perform BSE irregularly.** Cervical cancer screening with the Pap smear should begin three years after starting vaginal intercourse but no later than twenty-one years of age.*** Men should be informed of the benefits and limitations of PSA testing so that an informed decision can be made with the clinician.**** Samples should be obtained at home from three consecutive specimens. A single sample obtained during digital rectal examination by a clinician is not adequate.Source: American Cancer Society Guidelines for the Early Detection of Cancer, 2006

General Screening Regular health examinations should include inspection of the skin, mouth, lymph nodes, thyroid, testes, and ovaries for cancers and precancerous areas.

Breast Cancer Screening The American Cancer Society (ACS) recommends regular breast examinations by a clinician and mammography to detect breast cancer at early stages for women at average risk of this disease. For women between twenty and thirty-nine years old, examination should occur at least once every three years; for women over forty, clinical breast examination should take place annually.

Studies have shown that mammography, done on a regular basis, can decrease the number of deaths from breast cancer by as much as 30 percent. The ACS recommends that annual mammography should start at the age of forty for women at average risk. Although the appropriate starting age for mammography has been controversial in the past, more recent research has indicated that the benefit of mammography also applies to women between forty and fifty.

Use of digital mammography rather than film mammography may be beneficial for women who are under fifty, have dense breast tissue, or are premenopausal or perimenopausal. Increasing numbers of mammography units across the United States are adopting this technology. However, it is important to emphasize that no woman should defer screening with a mammogram due to a lack of access to digital mammography.

Several groups of women are considered to be at increased risk for breast cancer. Individuals with a history of radiation therapy to the chest, a strong family history of breast and/or ovarian cancer, or a known or suspected genetic predisposition to breast cancer are more likely to develop breast cancer than women in the general population. In addition, women with a personal history of breast cancer or breast lesions such as lobular carcinoma in situ (LCIS) and atypical hyperplasia also have a risk of having a second breast abnormality, which may be cancerous. Individuals in these groups may need to start breast cancer screening earlier, to have clinical breast examinations more often, or to have different screening procedures than women in the general population. In most cases, high-risk women should start screening when they are ten years younger than the age of diagnosis for their youngest relative with breast or ovarian cancer. Individuals who have a known genetic predisposition may require screening even earlier. These individuals may also be candidates for prophylactic surgery or chemoprevention to reduce their risk.

One newer screening procedure for breast cancer is breast magnetic resonance imaging (MRI). The primary use of breast MRI at this time is to assess women with a known genetic predisposition for breast cancer. Screening of these individuals must often start at a younger age, when the breasts are denser and harder to evaluate with mammography. Currently, breast MRI is not recommended for screening in the general population.

Cervical Cancer Screening Invasive cervical cancer is often preceded by precancerous changes in cervical tissue that can be identified with a Papanicolaou (Pap) smear. Screening for cervical cancer has been shown to reduce the number of deaths from this cancer. The ACS recommends that screening should start three years after a women starts having intercourse, or no later than age twenty-one. There are two types of Pap smears in current use, the conventional Pap smear and the liquid-based Pap smear. The conventional Pap smear should be performed on an annual basis, and the liquid-based Pap smear may be performed every two years. Once a woman has reached the age of thirty, less frequent screening can be considered if her last three Pap tests were normal. The Pap smear can be used alone or in combination with testing for human papillomavirus (HPV), the virus that causes cervical cancer. After the age of seventy, a woman may also consider stopping screening if she has recently had three consecutive negative Pap smears.

Women who have had a total hysterectomy for a noncancerous reason do not need to continue having Pap smears. However, if a woman has had a subtotal hysterectomy or has a history of cervical cancer or precancerous conditions, she should continue to have regular screening even after surgery.

Women who have a history of exposure to DES (diethylstilbestrol) are at increased risk of cervical and vaginal cancers. Continued screening with a Pap smear after hysterectomy is still recommended in this high-risk group. Other women who are at increased risk of cervical cancer include those who are immunocompromised due to organ transplant, chronic steroid use, chemotherapy, or infection with the human immunodeficiency virus (HIV). These individuals may require more frequent screening and do not have a designated age at which screening should stop.

Colon Cancer Screening Multiple procedures are currently in use for screening for colorectal cancer. For individuals at average risk for colon cancer, screening should start at age fifty. The ACS recommends any of the following options:

• Fecal occult blood test (FOBT) or fecal immunochemical testing (FIT) every year.

• Flexible sigmoidoscopy every five years.

• FOBT every year with flexible sigmoidoscopy every five years.

• Double-contrast barium enema every five years.

• Colonoscopy every ten years.

The option of combined FOBT with flexible sigmoidoscopy is preferred to either option alone. However, no one measure is preferred by the ACS for individuals at average risk of colon cancer. The National Comprehensive Cancer Network (NCCN) guidelines state that their preferred recommendation is colonoscopy, and that the barium enema is the least preferred option. The NCCN guidelines do not recommend use of FOBT or flexible sigmoidoscopy alone.

Individuals who choose to use FOBT for screening should perform at-home testing of three consecutive stool specimens. An FOBT of stool obtained during a rectal examination by a clinician is not considered sufficient for screening purposes. Also, dietary restrictions must be followed in order for this test to be interpreted accurately.

Fecal immunochemical tests (FIT) are also known as immunologic fecal occult blood tests or immunoassay fecal occult blood tests. Like the FOBT, this test assesses stool for the presence of a blood protein; however, it may be more accurate in determining if stool blood is present from the bowel rather than from another site higher in the gastrointestinal tract. The ACS has included this test as part of their screening recommendations, but the NCCN guidelines consider it an approach that is still under investigation at this time.

Other methods for screening the colon are under development. “Virtual colonoscopy,” also known as computed tomography (CT) colonography, uses a CT scan to evaluate the colon for polyps or cancer. Like conventional colonoscopy, this test requires preparation of the bowel with a laxative regimen, and air is inserted in the bowel in order to improve viewing during the procedure. If polyps are found on this test, conventional colonoscopy is done to remove them. Another screening alternative currently under study involves testing of the stool for DNA changes associated with colon adenomas and cancers. Cells from the lining of the bowel are routinely sloughed off into the stool, and several different panels of genetic mutations have been proposed to look for cancer and precancerous changes in these cells. At this time, additional study is needed before these techniques can be used routinely for screening purposes in the general population.

Individuals who are considered to be at higher risk for colon cancer include those with inflammatory bowel disease, those who have previously had a colon cancer, and those who have had a type of colon polyp called an adenoma. Women who have had uterine or ovarian cancer prior to the age of sixty are also considered to be at increased risk for colon cancer. These individuals require earlier and more frequent colon screening, which should be done by colonoscopy.

Colonoscopy is also recommended for individuals who have a family history of colon cancer or a family history that suggests a genetic predisposition to colon cancer. The age to start screening depends on the age of the youngest individual in the family who has had colon cancer. In most cases, high-risk individuals should start screening when they are ten years younger than the age of diagnosis for their youngest relative with colon cancer or a related cancer.

Endometrial Cancer Screening At this time, the American Cancer Society does not recommend screening for endometrial cancer for women at average risk. The guidelines do suggest that all women should be informed of the symptoms of endometrial cancer and should report any unexpected vaginal bleeding to their health care provider promptly.

Women at high risk of endometrial cancer due to a possible genetic predisposition based on a strong family history may be recommended to have screening with transvaginal ultrasound and/or endometrial biopsy. However, these procedures are not recommended for screening women who are at average risk.

Lung Cancer Screening Screening for lung cancer is not currently recommended for individuals without symptoms, regardless of smoking history. However, studies are being conducted to determine if screening can decrease the number of deaths from this disease. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial is a 160,000-person study investigating whether chest X-rays can be used as a screening tool for smokers and nonsmokers. Spiral computed tomography (CT) scanning is another new tool that is being assessed for early detection of lung cancer in smokers. Nearly 50,000 current and former smokers have been enrolled in the National Lung Cancer Screening Trial, which is evaluating chest X-rays and CT scans as screening strategies.

Ovarian Cancer Screening Currently, screening for ovarian cancer is not recommended in the general population. Tests that have been proposed for screening include transvaginal ultrasound and a blood test called CA-125. These tests are not in use in the general population at this time because they can be abnormal when no cancer is present, and they can be normal even in the setting of cancer. The high rate of false positive results may lead to unnecessary surgical procedures, particularly in women under fifty years of age. Transvaginal ultrasound and CA-125 are currently being evaluated as screening measures for the general population in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Women who have a strong family history of breast or ovarian cancer are considered to be at increased risk of ovarian cancer. Screening with transvaginal ultrasound and CA-125 can be considered in these women, but the limitations of these tests should be discussed with a clinician before starting screening.

Prostate Cancer Screening Screening for prostate cancer remains a topic of considerable controversy. The American Cancer Society recommends that prostate cancer screening should be discussed with men ages fifty and over. Screening for prostate cancer consists of an examination of the prostate through the rectum and testing the blood for levels of prostate-specific antigen, or PSA. These tests should be performed on an annual basis for men who choose screening. However, men should also be informed of the limitations of PSA testing, since levels of the PSA protein can be elevated in conditions other than cancer and may be normal in the setting of cancer. Overall, about one-third of men with an elevated PSA level are found to have prostate cancer on biopsy.

Some groups have advocated starting screening with PSA testing in men at the age of forty and at average risk for prostate cancer. Men with a normal test at age forty would have the test repeated at age forty-five, and would start annual screening at age fifty. This approach is not universally accepted in average-risk men at the current time.

Two types of PSA tests exist, the complexed PSA and the total PSA. Either may be used, but it is important that the same test be used over time. Another test that can be helpful in assessing for prostate cancer is the PSA velocity, which is the average increase in PSA level in three measurements over eighteen months. Other forms of PSA testing are also in development but are not in current widespread clinical use.

Men who are considered at high risk for prostate cancer include African-Americans and those with a family history of prostate cancer. The ACS recommends starting screening at age forty-five in those of African-American descent and in those who have one close relative with a history of prostate cancer before the age of sixty-five. If an individual has more than one close relative with prostate cancer at an early age, screening should begin at age forty.

Preventing Cancer Through Lifestyle Choices and Clinical Trials

Studies are confirming what scientists, doctors, and many others have suspected for years—lifestyle does make a difference in our risk for developing cancer. As much as 60 percent of cancers may be the direct results of the lifestyle choices we make. Although many people have become more aware of cancer risk factors, many still resist changing their health habits. The success we can have in the fight against cancer hinges on two things that are within our power:

• increasing our understanding of the causes of cancer and cancer risk factors, and

• being willing to act upon that information to allow early detection of cancer and to implement lifestyle changes that reduce our chances of developing cancer.

Successful prevention and early detection require that we assume greater responsibility for our health. We also must work in partnership with health care professionals to make personal choices and risk-reducing decisions.

How Can You Reduce Cancer Risk?

Don’t Smoke Smoking cessation is the single most important change you can make to improve your health. Nicotine is an addiction, perhaps the most deadly form of drug dependence, and it is a difficult habit to break. But quitting is possible, as over 46 million ex-smokers in the United States can confirm.

Quitting smoking reduces risk for heart disease and cancer and lengthens life. For former smokers who have quit for ten years, the risk of lung cancer is half that of current smokers. This risk falls to as low as 10 percent for ex-smokers who have quit for thirty years or more. The risk for cancers of the mouth, throat, and esophagus lessens significantly five years after quitting, and the risk of developing bladder or cervical cancer also decreases after just a few years of being nicotine-free.

Individual plans and group support programs can increase the success rate in the attempt to stop smoking. Many health care providers offer practical counseling, including problem-solving and skills training, social support as part of treatment, and social support outside of treatment. The National Cancer Institute (NCI) conducts research on smoking cessation and works with other government agencies and nonprofit organizations to promote programs that reduce the rates of illness and death associated with smoking. Several NCI and American Cancer Society (ACS) publications provide tips on smoking cessation and dealing with secondhand smoke at work or in public places. These materials are available from the NCI-supported Cancer Information Service (CIS) at

800-4-CANCER (800-422-6237)

TTY (for deaf and hard-of-hearing callers): 800-332-8615

www.cancer .gov/aboutnci/cis

Another important resource is the National Network of Tobacco Cessation Quitlines, which can be reached at 800-QUITNOW (800-784-8669). This number will automatically route you to the quitline for your state or to the quitline for the National Cancer Institute if your state does not have a quitline.

Medications can also be used in combination with support and counseling. Nicotine replacement products deliver small, steady doses of nicotine into the body, which help to relieve nicotine withdrawal symptoms. These replacement products are available in a variety of forms, including patches, gum, nasal sprays, and inhalers. Bupropion (Zyban), a prescription drug approved by the FDA in 1997 to treat nicotine addiction, helps Wellbutrin to reduce nicotine withdrawal symptoms and the urge to smoke. This medication is generally well tolerated but should not be used by people with seizure conditions or eating disorders. Another newly approved medication for smoking cessation is Chantix, also known as varenicline tartiate. In addition to preventing cravings, this medication blocks the nicotine receptors in the brain to diminish satisfaction from nicotine. Your physician can help you determine if these medications are appropriate for you.

Finally, it’s important not to become discouraged if your first attempt at quitting is not successful. Most people try to quit smoking five to seven times before they can eliminate nicotine from their lives. Consider each attempt a learning experience that will build toward success in a future attempt, and don’t give up!

Watch Your Diet No diet is guaranteed to prevent cancer, but a diet low in fat with a wide variety of fruits, vegetables, and whole-grain products may reduce cancer risk. Table 1 lists the results of some major dietary studies in cancer prevention, and Table 4 summarizes cancer-risk-reducing dietary guidelines issued by the ACS and the American Institute for Cancer Research. Other dietary suggestions include using herbs and spices to season foods and limiting the consumption of salted foods and table salt, not eating food that has not been appropriately refrigerated, and not eating charred food. Studies from the NCI have documented that microwaving meats for two minutes and discarding the juices prior to cooking reduces the potential carcinogen content of these foods by as much as 90 percent. For people who follow the recommended dietary guidelines, supplements are not currently recommended for reducing cancer risk.

Table 4. Dietary Guidelines for Reducing Cancer RiskEat a variety of healthful foods, with an emphasis on plant sources.• Eat 5 or more servings of a variety of vegetables and fruits each day.• Choose whole grains in preference to processed (refined) grains and sugars.• Limit consumption of red meats, especially those high in fat and processed.• Choose foods that allow you to maintain a healthful weight.Adopt a physically active lifestyle.• Adults: Engage in at least moderate activity for 30 minutes or more on 5 or more days of the week. Moderate to vigorous activity lasting at least 45 minutes on 5 or more days per week may further enhance reductions in the risk of breast and colon cancers.• Children and adolescents: Engage in at least 60 minutes per day of moderate to vigorous physical activity at least 5 days per week.Maintain a healthful weight throughout life.• Balance caloric intake with physical activity.• Lose weight if you are currently overweight.Limit consumption of alcoholic beverages if you drink at all.Source: American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention, 2001

Exercise Regularly Increased physical activity helps maintain an ideal weight and prevent obesity, a cancer risk factor. Weight control can reduce excess hormone production that may promote cancer growth. Exercise may also reduce the production of tumor-promoting prostaglandins, boost the body’s natural defenses, and strengthen the immune system to protect against cancer.

The American Cancer Society recommends that adults should engage in moderate exercise for at least thirty minutes a day, five or more days per week. Increasing the length of exercise to forty-five minutes or more may provide additional protection against breast and colon cancers. Children are recommended to exercise for at least sixty minutes per day for at least five days per week.

Ways to increase physical activity in daily life include using stairs instead of elevators, parking far away from your destination, and walking or riding a bike to work. Moderate exercise, such as brisk walking, helps burn fat, makes muscles firm, and builds bone strength.

Practice Safe Sex Use of condoms can prevent the transmission of human papillomavirus, the virus associated with cervical and other types of cancer. Know your partner’s history of sexually transmitted diseases, such as AIDS and HIV, and avoid having sex with multiple partners.

Limit Consumption of Alcoholic Beverages Because of the increased risk of cancers that are associated with alcohol use, the American Cancer Society recommends limiting alcohol use to two drinks per day for men. Women should limit their intake of alcohol to one drink per day due to slower metabolism of alcohol. A drink is 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of 80-proof liquor.

Avoid Excessive Exposure to the Sun’s Rays Although existing damage cannot be reversed, we can limit further insult to our skin by practicing sun safety. These safety measures include staying out of the sunshine during the peak hours of ten A.M. to four P.M., wearing protective clothing and hats, using sunscreen with a sun protection factor (SPF) of 30 or more, and avoiding artificial tanning devices. The higher the sunscreen’s SPF number, the longer the protection period; however, all sunscreen should be reapplied periodically, and particularly after swimming or perspiring heavily. People with light complexions, blue eyes, blond or red hair, or a tendency to freckle easily, need to be especially vigilant because they don’t have as much sun-protective melanin in their skin. Fundamental skin cancer prevention measures are summarized in Table 5.

Table 5. Skin Cancer Prevention and DetectionAvoid the midday sun between ten A.M. and four P.M.Wear a sunscreen with SPF 30 or greater.Cover up with protective clothing and a hat.Bring any moles to the attention of your doctor if they have one or more of the “ABCDEs”:A—asymmetry (one-half looks different from the other)C—color (different colors in the same mole)D—diameter (larger than a pencil eraser)E—evolving (a change in a mole)

Exercise Caution in Taking Hormone Replacements Women should talk with their health care providers so they can make an informed decision about using hormone replacement therapy (HRT). HRT can be very effective in treating the symptoms of menopause and preventing bone loss, but other medications and habits may also be effective. For example, many women choose to reduce the risks of osteoporosis by exercising regularly, eating a balanced diet, and taking calcium supplementation and/or a bone-strengthening medication, such as raloxifene (Evista) or alendronate (Fosamax). Ultimately, each woman’s decision about whether to take HRT and the duration of its use must be an individual one based on information she has received from her health care provider. This decision should also be based on the woman’s personal and family history of cancer, heart disease, stroke, and osteoporosis. The current recommendation from the FDA is to use the lowest effective dose of hormone replacement therapy for the shortest duration of time.

Chemoprevention Chemoprevention involves the use of a dietary nutrient or drug to halt or reverse the process of carcinogenesis. At present, prescription chemoprevention medications are targeted only toward individuals with an increased risk of specific cancers. Several chemopreventive agents have been shown to be effective in large cancer prevention studies. Table 6 lists the results of some completed chemoprevention trials. These agents are not without side effects, so those taking them should receive close medical supervision.

Table 6. Results of Selected Completed Large Chemoprevention TrialsAlpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study (ATBC)Lung cancer in male cigarette smokers

Secondary target: prostate cancer in male cigarette smokers

Oral alpha-tocopherol (vitamin E) and beta-caroteneAlpha-tocopherol did not reduce lung cancer incidence; 18% higher incidence of lung cancer with beta-carotene and 8% more deaths.

Alpha-tocopherol reduced prostate cancer incidence in men ages 50 to 69 by 32% and prostate cancer deaths by 41%.

Breast Cancer Prevention Trial (BCPT)Breast cancer in high-risk womenOral tamoxifen (Nolvadex) versus placeboTamoxifen reduced incidence of invasive breast cancer by 49%; similar reduction in noninvasive breast cancer. Approximately 50% increase in curable uterine cancer with tamoxifen.Beta-Carotene and Retinole Efficacy Trial (CARET)Lung cancer in heavy smokers and asbestos workersOral beta-carotene and retinol (vitamin A) versus placeboBeta-carotene and retinol groups had 28% more lung cancers diagnosed and 17% more deaths than in placebo group.Nutritional Prevention of Cancer (NPC) Chemoprevention TrialSecondary cancers in people with a history of skin cancerOral selenium (in yeast) versus placeboProstate, lung, and colorectal cancers were lower in selenium group; selenium group had 17% fewer cancers overall and fewer deaths from lung cancer.All cancers in male physiciansBeta-carotene produced neither benefit nor harm for cancer incidence or deaths, but only 11% of physicians were current smokers.Prostate Cancer Prevention Trial (PCPT)Finasteride (Proscar) versus placeboFinasteride reduced prevalence of prostate cancer by 25%; higher-grade prostate cancers were more likely in finasteride group.All cancers in female health professionalsLow-dose aspirin did not reduce risk of cancers, with possible exception of lung cancer. Vitamin E did not reduce cancer incidence or overall deaths.Study of Tamoxifen and Raloxifene (STAR)Breast cancer in postmenopausal women at increased riskTamoxifen (Nolvadex) versus raloxifene (Evista)Tamoxifen and raloxifene groups had similar rates of invasive breast cancer; noninvasive breast cancer was increased and uterine cancer was decreased in raloxifene group.All cancers and prostate cancer in male physicians

Secondary target: colon cancer

Vitamin E, vitamin C, beta-carotene, and multivitamin versus placebosSelenium and Vitamin E Cancer Prevention Trial (SELECT)Oral selenium, vitamin E, or both, versus placeboRecruitment closed 2004. Results anticipated in 2011.

One of the main examples of chemoprevention is the use of tamoxifen (Nolvadex) to prevent breast cancer. Based on a 50 percent risk reduction in the Breast Cancer Prevention Trial, tamoxifen has been approved by the Food and Drug Administration (FDA) to reduce the risk of breast cancer in women who are at high risk. This drug can be a valuable tool for reducing breast cancer risk in women who have a strong family history of breast cancer or have a personal history of premalignant breast conditions; however, it is not recommended for women at average risk of breast cancer due to uncommon but serious side effects, including increased risk of blood clots, stroke, and uterine cancer.

More recently, results of the Study of Tamoxifen and Raloxifene (STAR) trial have shown that raloxifene (Evista) is another drug that can be used for breast cancer prevention. Both raloxifene and tamoxifen reduced the risk of breast cancer in postmenopausal, high-risk women by about 50 percent. In addition, both medications are highly successful strategies for reducing the risk of bone fractures in women. Women in the raloxifene group had fewer blood clots and fewer uterine cancers than those in the tamoxifen group. However, the women taking raloxifene had more noninvasive cancers, or carcinomas in situ, than the women taking tamoxifen. Although in situ cancers cannot spread to other parts of the body, it is uncertain why these lesions were more frequent in this group. These results suggest that raloxifene is a second option for risk reduction in postmenopausal women. The STAR trial did not include premenopausal women, so additional studies will need to be done to determine if raloxifene is also beneficial in women who have not yet undergone menopause.

Another important area of investigation in chemoprevention is the use of nonsteroidal anti-inflammatory drugs to prevent colon, breast, and other types of cancer in high-risk individuals. Regular use of these medications may decrease the risk of premalignant colon adenomas by as much as 45 percent in individuals who have already had a colon adenoma. Due to the cardiovascular effects associated with COX-2 inhibitors (types of nonsteroidal anti-inflammatory drugs), routine use of these medications for the prevention of cancer is not currently recommended outside of a clinical trial.

Human Papillomavirus Vaccine The human papillomavirus is an important cause of many cases of cervical cancer. Most women are exposed to this virus only for a brief period of time, but some women have persistent infection that can lead to cervical cancer. Gardasil, a vaccination against human papillomavirus, has recently been approved by the FDA. This vaccination is targeted toward girls ages eleven to twelve, but it may be administered to girls as young as nine and women as old as twenty-six. The vaccination consists of three shots given over a six-month period. Although this vaccination is highly effective in preventing most cervical cancers, women who have been vaccinated should still have regular screening with Pap smears.

Joining the National Fight Against Cancer

Community-Based Cancer Prevention and Control Initiatives The National Cancer Institute, the Centers for Disease Control and Prevention, and the American Cancer Society have launched large cancer prevention research studies and programs. These community-based efforts are designed to further our understanding of ways to prevent, detect, and control cancer.

Ongoing cancer prevention trials offer the public a way to participate in research, and advance the science of cancer prevention. These studies and programs target common cancer sites, such as the breast, lung, prostate, and colon. Listed below are examples of several ongoing cancer prevention studies taking place in multiple areas across the United States. If you are interested in participating in a cancer screening or cancer prevention trial, your physician may be able to provide you with information about studies in your area.

Vitamin D/Calcium Polyp Prevention Study This study will assess the effects of calcium and/or vitamin D supplementation on recurrence of colon adenomas. Individuals who have recently had a colon adenoma removed are eligible for participation, and approximately 2,500 participants will be enrolled in centers across the country. The prevention target is new colon adenomas seen on follow-up colonoscopy, which is done three to five years later.

Study of Selenium in Patients with Adenomatous Colorectal Polyps This trial is studying the micronutrient selenium to determine if it can effectively prevent the recurrence of colon adenomas in individuals with a history of adenomas. In order to participate, individuals must have a history of having a colon adenoma removed within the last six months. Approximately 1,600 participants will randomly be assigned to selenium or placebo, and the primary assessment will be the rate of adenoma recurrence after 2.5 to 5 years.

Computed Tomographic Colonography (Virtual Colonoscopy) Screening for Colon Cancer This study will investigate the use of computed tomography (CT) scans in screening for colon cancer. Participants must be at least fifty years old and due for a screening colonoscopy. Colonoscopy will also be performed for participants as part of the study. Multiple sites are participating in this study across the United States.

Cancer Control Advocacy Legislative action and public policy can complement research and education to reduce cancer incidence and deaths. To accomplish this goal, people need to speak out and demand action from Congress and from state and municipal bodies. Such public advocacy has already been successful. For example, mammography facilities in the United States are now required to meet strict accreditation and inspection guidelines. Smoke-free public buildings and work sites are commonplace. The government budget for breast cancer research has increased, largely from results of demands by grassroots organizations. Medicare now reimburses for screening mammography.

Additional public advocacy is warranted for prohibiting sales of tobacco products to youth and increasing penalties to vendors who sell to minors. Increasing access to and insurance coverage for early-detection and screening procedures is still on the horizon.

Advocacy is taken seriously by the NCI. The Director’s Consumer Liaison Group advises and makes recommendations to the NCI director from the perspective and viewpoint of cancer consumer advocates on a wide variety of issues, programs, and research priorities. The committee serves as a channel for consumer advocates to voice their views and concerns.

Resources on the Internet

American Cancer Society:

www.cancer .org/docroot/home/index.asp

Cancer Research and Prevention Foundation:

www.preventcancer .org/index.cfm

National Cancer Institute (Information on clinical trials):

www.cancer .gov/clinicaltrials

My Pyramid (Information for a healthy diet):

www.choosemyplate .gov

Smoking Cessation Information:

www.smokefree .gov